Advances in technology for the laboratory diagnosis of individuals with HIV/AIDS coinfected with Mycobacterium tuberculosis  

作　　者：Jin Sun Xiaoxu Han Hongxia Yan Xin Zhang Taiyi Jiang Tong Zhang Hao Wu Grigory Kaminskiy Yingmin Ma Eduard Karamov Bin Su 

机构地区：[1]Beijing Key Laboratory for HIV/AIDS Research,Clinical and Research Center for Infectious Diseases,Beijing Youan Hospital,Capital Medical University,Beijing 100069,China [2]State Health Organization Tula Regional Center for Control and Prevention of AIDS and Infectious Diseases,Tula 300002,Russia [3]Department of Respiratory and Critical Care Medicine,Beijing Youan Hospital,Capital Medical University,Beijing 100069,China [4]Gamaleya National Research Centre for Epidemiology and Microbiology of the Ministry of Health of the Russian Federation,Moscow 123098,Russia

出　　处：《Biosafety and Health》2024年第3期133-142,共10页生物安全与健康（英文）

基　　金：the Beijing Natural Science Foundation(Z220018);the Belt and Road International Health Cooperation Project of Beijing Municipal Health Commission,the National Key R&D Program of China(2023YFE0116000,2023YFC2308300,2023YFC2308302);the High-Level Public Health Specialized Talents Project of Beijing Municipal Health Commission(2022-2-018,2022-1-007);the Beijing Key Laboratory for HIV/AIDS Research(BZ0089).The funders had no role in study design,data collection and analysis,decision to publish,or preparation of the manuscript.

摘　　要：The high morbidity and mortality rate of individuals with human immunodeficiency virus(HIV)/acquired immunodeficiency syndrome(AIDS)coinfected with Mycobacterium tuberculosis(MTB)is a tough challenge for current global tuberculosis prevention and control efforts.HIV/MTB coinfection is more complex than a single infection,and the interaction between the two diseases aggravates the deterioration caused by the disease,resulting in increased hospitalizations and deaths.Rapid screening and early diagnosis facilitate the timely initiation of anti-tuberculosis treatment in HIV/MTB coinfected individuals,thereby reducing transmission and the incidence of adverse prognoses.To date,pathogenic detection has remained the gold standard for diagnosing tuberculosis,but its sensitivity and specificity are greatly affected by the body's immune status,which limits its application in the diagnosis of HIV/MTB coinfection.Recently,immunology and molecular detection technology has developed rapidly.New detection technologies,such as interferon-γ release assays,interferon-gamma inducible protein 10,and GeneXpert MTB/RIF assay have overcome the limitations of traditional detection methods,significantly improved the sensitivity and specificity of tuberculosis diagnosis,and brought new hope to the detection of HIV/MTB coinfection.In this article,the principle,scope of application,and latest research progress of relevant detection methods are reviewed to provide a reference for the early diagnosis of HIV/MTB coinfection.

关 键 词：Human immunodeficiency virus(HIV) Mycobacterium tuberculosis(MTB)coinfection Mycobacterium tuberculosis(MTB) Early diagnosis 

分 类 号：R446.5[医药卫生—诊断学] R512.91[医药卫生—临床医学] R52