Evaluation of antibody responses in healthy individuals receiving SARS-CoV-2 inactivated vaccines  

作　　者：Ziyu Liu Liyan Cai Man Xing Nan Qiao Jiaojiao Liu Xuejun Li Chiyu Zhang Naijun Tang Zhelong Xu Yingying Guo Renfei Lu Dongming Zhou 

机构地区：[1]Department of Pathogen Biology,School of Basic Medical Sciences,Tianjin Medical University,Tianjin 300070,China [2]Physical examination center,Affiliated Nantong Hospital 3 of Nantong University,Nantong 226000,China [3]Shanghai Public Health Clinical Center,Fudan University,Shanghai 201508,China [4]Department of Occupational and Environmental Health,School of Public Health,Tianjin Medical University,Tianjin 300070,China [5]Clinical Laboratory,Affiliated Nantong Hospital 3 of Nantong University,Nantong 226000,China

出　　处：《Biosafety and Health》2024年第3期153-164,共12页生物安全与健康（英文）

基　　金：the Key Project of the Natural Science Foundation of Tianjin,China(No.20JCZDJC00090).The funders played no role in the study design,data collection and analysis,decision to publish,or manuscript preparation.

摘　　要：Inactivated coronavirus disease 2019(COVID-19)vaccines such as CoronaVac and BBIBP-CorV have been widely used in China.However,more investigation is still needed to understand antibodies'duration and effectiveness against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)variants in the real world.In this study,575 participants who had been vaccinated with two or three doses of the inactivated vaccine were recruited.Serum samples were collected and tested for anti-spike IgG and neutralizing antibodies against SARS-CoV-2(original strain,Dela,and Omicron).Unsurprisingly,a third dose of the vaccine significantly enhanced antibody responses against SARS-CoV-2 and its variants.However,despite a booster dose,the neutralizing antibody levels against Omicron,particularly the BA.5.2 subvariant,remained low.There was no sex bias,but an age bias was observed.Notably,the predominant IgG subclass antibodies were IgG1 and IgG2,with a much lower level of IgG4.After the booster shot,the ratio of IgG4 to IgG1 significantly increased.The observation of IgG1 to the IgG4 class switch after repeated inactivated vaccinations underscores the importance of continuous monitoring of subclass antibody responses.Further clinical investigations are required to understand the implications of this class switch for optimizing immunization strategies.

关 键 词：Variant of concern(VOC) Inactivated vaccines Serological study IgG subclasses Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) 

分 类 号：R392[医药卫生—免疫学]