高效液相色谱-质谱联用技术在药物代谢分析中的应用  

Application of HPLC-MS for the analysis of drug metabolism

作　　者：赵颖辉 邹开鲁 ZHAO Yinghui;ZOU Kailu(Sinopharm Group Industrial Co.,Ltd.,Beijing 100031,China;Hainan Haiyao Co.,Ltd.,Beijing 101300,China)

机构地区：[1]国药集团工业有限公司,北京100031 [2]海南海药股份有限公司,北京101300

出　　处：《中国高新科技》2024年第13期155-157,共3页

摘　　要：在药物代谢分析中,高效液相色谱-质谱联用技术的应用越来越广泛,其不仅具备检验检测高精度的技术特点,同时还能充分发挥高效分离能力,避免药物在高温下分解,提高药物检验过程中的完整度,借助于数据分析,实现对药物代谢功能、代谢流程的标准化检验。鉴于此,本文首先对高效液相色谱-质谱联用技术的基本原理与特点进行分析,提出高效液相色谱-质谱联用技术在药物代谢分析中的应用要点,以供参考。Drug metabolism analysis,high performance liquid chromatography-mass spectrometry technology application more and more widely,it not only has the technical characteristics of high precision,and give full play to the efficient separation ability,avoid drug decomposition under high temperature,improve the integrity of drug inspection process,with the help of data analysis,realize the function of drug metabolism,metabolic process standardization test.In view of this,the paper first analyzes the basic principles and characteristics of HPLC-MS technology,and proposes the application points of HPLC-MS in drug metabolism analysis for reference.

关 键 词：高效液相色谱-质谱联用 药物代谢 药物检验 

分 类 号：TQ460[化学工程—制药化工]