人乳头状瘤病毒基因分型检测在宫颈病变中的应用价值  

Application value of HPV genotyping detection in cervical lesions

作　　者：李秋平 揭雅萍 刘云 Li Qiuping;Jie Yaping;Liu Yun(Department of Laboratory Medicine,Shicheng Maternal and Child Health Hospital of Jiangxi Province,Ganzhou 342706,China)

机构地区：[1]江西省赣州市石城县妇幼保健院检验科,赣州342706

出　　处：《实用医技杂志》2024年第6期435-438,共4页Journal of Practical Medical Techniques

摘　　要：目的分析人乳头瘤状病毒(HPV)基因分型检测在宫颈病变中的应用价值。方法回顾性分析2021年1月至2023年12月3760例进行宫颈病变筛查且HPV阳性女性的临床资料,受检女性均进行HPV基因分型检测与液基细胞学检测(TCT)检测,以宫颈活检病理组织学为金标准,确诊68例存在宫颈病变[宫颈上皮内瘤变(CINⅠ~Ⅲ:65例;癌变:3例)]。分析HPV阳性率;HPV基因分型分布情况;不同宫颈病变者高危型HPV及TCT检查情况。结果HPV单一感染占比较大,为73.99%(2782/3760),高危型感染占73.94%(2780/3760),低危型感染占0.05%(2/3760);HPV 52+其他分型、HPV 53+其他分型、HPV58+其他分型为最主要的HPV多重感染类型;HPV基因分型检查对宫颈病变的检出率高于TCT检查,差异有统计学意义(P<0.05)。结论HPV基因分型检测有助于了解患者HPV感染情况,对宫颈病变具有较高的临床辅助检查价值。Objective To analyze the application value of human papillomavirus(HPV)genotyping detection in cervical lesions.Methods The clinical data of 3760 women who underwent cervical lesion screening and were HPV positive from January 2021 to December 2023 were retrospectively analyzed.All the women underwent HPV genotyping and liquid based cytology test(TCT).As a pathological examination,cervical biopsy pathology was taken as the gold standard,68 cases were confirmed to have cervical lesions(CINⅠ~Ⅲ:65 cases;canceration:3 cases).The positive rate of HPV,HPV genotyping distribution,high risk HPV and TCT examination in patients with different cervical lesions were analyzed.Results HPV single infection accounted for 73.99%(2782/3760),highrisk infection accounted for 73.94%(2780/3760),lowrisk infection accounted for 0.05%(2/3760).HPV 52+other subtypes,HPV 53+other subtypes and HPV58+other subtypes were the main types of HPV multiple infection.The detection rate of HPV genotyping for cervical lesions was higher than that of TCT,and the difference was statistically significant(P<0.05).Conclusion HPV genotyping test is helpful to understand the HPV infection situation of patients,and has high clinical auxiliary examination value for cervical lesions.

关 键 词：宫颈疾病 宫颈肿瘤 人乳头瘤状病毒 基因分型技术 

分 类 号：R711.3[医药卫生—妇产科学] R737.33[医药卫生—临床医学]