东北雷公藤化学成分研究  

Chemical Constituents of Tripterygium regelii

作　　者：孙妍 孙锦涛 冷爱晶[3] 李大伟 王超[2] 冯磊 SUN Yan;SUN Jin-tao;LENG Ai-jing;LI Da-wei;WANG Chao;FENG Lei(College of Pharmacy,Hangzhou Normal University,Hangzhou 311121,China;College of Pharmacy,Dalian Medical University,Dalian 116044,China;The First Affiliated Hospital of Dalian Medical University,Dalian 116011,China;The Second Affiliated Hospital of Dalian Medical University,Dalian 116023,China)

机构地区：[1]杭州师范大学药学院,浙江杭州311121 [2]大连医科大学药学院,辽宁大连116044 [3]大连医科大学附属第一医院,辽宁大连116011 [4]大连医科大学附属第二医院,辽宁大连116023

出　　处：《中药材》2024年第2期371-374,共4页Journal of Chinese Medicinal Materials

基　　金：国家自然科学基金资助项目(81872970);辽宁省自然科学基金资助项目(2021-MS-283)。

摘　　要：目的:研究卫矛科雷公藤属植物东北雷公藤Tripterygium regelii Sprague et Takeda的化学成分。方法:利用硅胶柱色谱和高效液相等色谱方法对东北雷公藤根的醇提物的化学成分进行分离纯化,根据理化常数测定及波谱数据分析鉴定化合物结构。结果:从东北雷公藤根的醇提物中分离得到13个化合物,分别鉴定为:新海胆灵A(1)、β-谷甾醇(2)、(+)-丁香脂素(3)、calolongic acid(4)、caloteysmannic acid(5)、没食子儿茶素(6)、表没食子儿茶素(7)、儿茶素(8)、表儿茶素(9)、()-4′-O-methyl-epi-gallocatechin(10)、香草酸(11)、丁香酸(12)、3,4,5-三甲氧基苯酚(13)。结论:其中,化合物1、4~7、9~13为首次从该植物中分离得到。Objective:To study the chemical constituents of Tripterygium regelii.Methods:The chemical constituents from the ethanol extract of Tripterygium regelii were isolated and purified by column chromatography on silica gel and HPLC.The structures were identified on the basis of physicochemical properties and spectral data.Results:Thirteen compounds were isolated from the roots of Tripterygium regelii and identified as neoechinulin A(1),β-sitosterol(2),(+)-syringaresinol(3),calolongic acid(4),caloteysmannic acid(5),gallocatechin(6),epi-gallocatechin(7),catechin(8),epi-catechin(9),()-4′-O-methyl-epi-gallocatechin(10),vanillic acid(11),syringic acid(12),3,4,5-trimethoxyphenol(13),repectively.Conclusion:Among them,compounds 1,4 to 7,9 to 13 are isolated from Tripterygium regelii for the first time.

关 键 词：东北雷公藤 化学成分 

分 类 号：R284.1[医药卫生—中药学] R284.2[医药卫生—中医学]