天然二萜化合物抗肿瘤作用的研究进展  

Research progress on antitumor effects of natural diterpenoids

作　　者：石小艺 程菊 陈建军 杨立苑 陈晓峥 刘秀珠 Amna RASHEED 谢小冬 SHI Xiaoyi;CHENG Ju;CHEN Jianjun;YANG Liyuan;CHEN Xiaozheng;LIU Xiuzhu;Amna RASHEED;XIE Xiaodong(Gansu University of Chinese Medicine,Lanzhou,Gansu,730000 P.R.China;Institute of Genetics,School of Basic Medicine,Lanzhou University,Lanzhou,Gansu,730000 P.R.China;State Key Laboratory of Applied Organic Chemistry,Lanzhou University,Lanzhou,Gansu,730000 P.R.China)

机构地区：[1]甘肃中医药大学,甘肃兰州730000 [2]兰州大学基础医学院遗传学研究所,甘肃兰州730000 [3]兰州大学功能有机分子化学国家重点实验室,甘肃兰州730000

出　　处：《华西药学杂志》2024年第4期471-475,共5页West China Journal of Pharmaceutical Sciences

基　　金：兰州市科技局新冠肺炎防控技术研究项目(2020-XG-37);甘肃省科技重大专项项目(22ZD1FA001)。

摘　　要：二萜化合物在植物、真菌、昆虫、海洋生物等中广泛存在,结构复杂、多变,生物活性多样。现概述天然二萜化合物抗肿瘤作用的相关通路及机制,从肿瘤信号通路的角度解析药物的抗肿瘤机制,为二萜化合物在抗肿瘤新药的研发及临床应用提供依据。Diterpenoid compounds are widely distributed in plants,fungi,insects,and marine organisms,with complex and diverse structures and diverse biological activities.This article provides an overview of the relevant pathways and mechanisms of anti-tumor effects of natural diterpenoid compounds,analyzes the anti-tumor mechanism of drugs from the perspective of tumor signaling pathways,and provides a theoretical basis for the development and clinical application of diterpenoids in the development of anti-tumor new drugs.

关 键 词：天然化合物 二萜化合物 肿瘤 高效低毒 信号通路 分子机制 综述 

分 类 号：R96[医药卫生—药理学]