贵州省少数民族人群体重矫正腰围指数与心血管疾病的关联性研究  

Association between weight adjusted waist index and cardiovascular disease among ethnic minority population in Guizhou Province

作　　者：申毅力 吴申燕 钟建琴 胡宇欣 陈成 张宇馨 洪峰[1] SHEN Yi-li;WU Shen-yan;ZHONG Jian-qin;HU Yu-xin;CHEN Cheng;ZHANG Yu-xin;HONG Feng(School of Public Health,Key Laboratory of Environmental Pollution Monitoring and Disease Control of Ministry of Education,Guizhou Medical University,Guiyang,Guizhou 561113,China)

机构地区：[1]贵州医科大学公共卫生与健康学院,环境污染与疾病监控教育部重点实验室,贵州贵阳561113

出　　处：《现代预防医学》2024年第15期2689-2694,共6页Modern Preventive Medicine

基　　金：国家重点研发计划课题(2017YFC0907301);国家自然科学基金(82173566)。

摘　　要：目的了解贵州省少数民族人群体重矫正腰围指数(weight adjusted waist index,WWI)与心血管疾病之间的关联性。方法基于“西南区域少数民族聚集地世居自然人群队列研究”,于2018—2019年在贵州省黔东南、黔南地区对30~79岁侗族、苗族、布依族人群开展基线调查。采用logistic回归分析贵州省少数民族人群WWI与心血管疾病及其亚型的关联,采用限制性立方样条(restricted cubic spline,RCS)探讨WWI与心血管疾病的剂量反应关系,采用相乘、相加模型分析WWI与饮酒情况、糖尿病交互作用对心血管疾病的影响。结果共纳入16993人,贵州省少数民族人群心血管疾病检出率为3.1%。调整所有协变量后,与WWI最低分位(Q1)相比,WWI第三分位(Q3)、第四分位(Q4)患心血管疾病的OR值分别为1.448(95%CI:1.089~1.924)、1.350(95%CI:1.007~1.811)。RCS显示,WWI与心血管疾病呈近似“S”型非线性剂量反应关系(P for nonlinear=0.029)。相乘交互作用显示,WWI与饮酒存在正向相乘交互作用(OR=2.36,95%CI:1.22~4.55),WWI与糖尿病不存在相乘交互作用(OR=0.55,95%CI:0.30~1.00)。结论贵州省少数民族人群WWI与心血管疾病呈正相关,且呈非线性剂量反应关系,WWI与饮酒对心血管疾病存在相乘交互作用。Objective To investigate the association between Weight Adjusted Waist Index(WWI)and cardiovascular disease among ethnic minority populations in Guizhou Province.Methods Based on the Longitudinal Study of Natural Population in Southwest Minority Aggregated Areas,a baseline survey was conducted among Dong,Miao,and Buyi ethnic groups aged 30 to 79 years in Qiandongnan and Qiannan regions of Guizhou Province from 2018 to 2019.Logistic regression analysis was performed to examine the association between WWI and cardiovascular disease and its subtypes among the ethnic minority population in Guizhou Province.Restricted Cubic Spline(RCS)was employed to explore the dose-response relationship between WWI and cardiovascular disease.Multiplicative and additive models were used to analyze the interaction effects of WWI with alcohol consumption and diabetes on cardiovascular disease.Results A total of 16993 individuals were included,and the prevalence of cardiovascular disease among the ethnic minority population in Guizhou Province was 3.1%.After adjusting for all covariates,compared to the lowest quartile of WWI(Q1),the odds ratios(ORs)for cardiovascular disease in the third quartile(Q3)and the fourth quartile(Q4)of WWI were 1.448(95%CI:1.089-1.924)and 1.350(95%CI:1.007-1.811),respectively.The RCS showed an approximately S-shaped non-linear dose-response relationship between WWI and cardiovascular disease(P for nonlinear=0.029).The multiplicative interaction analysis revealed a positive interaction between WWI and alcohol consumption(OR=2.36,95%CI:1.22-4.55),while no multiplicative interaction was found between WWI and diabetes(OR=0.55,95%CI:0.30-1.00).Conclusion WWI is positively associated with cardiovascular disease among ethnic minority populations in Guizhou Province,and there is a non-linear dose-response relationship.Additionally,there is a multiplicative interaction between WWI and alcohol consumption on cardiovascular disease.

关 键 词：体重矫正腰围指数 心血管疾病 少数民族 剂量反应关系 交互作用 

分 类 号：R54[医药卫生—心血管疾病]