烟瘾者海马及岛叶亚区与其他脑区间静息态功能连接分析  

Resting-state functional connectivity of hippocampal and insular subregions with other regions of the whole brain in nicotine addicts

作　　者：汪涛[1] 谢梅 陈懂燕 李志强 张建军[1] Wang Tao;Xie Mei;Chen Dongyan;Li Zhiqiang;Zhang Jianjun(Department of Radiology,Zhejiang Hospital,Hangzhou 310009,China)

机构地区：[1]浙江医院放射科,杭州310009

出　　处：《中华神经医学杂志》2024年第7期669-675,共7页Chinese Journal of Neuromedicine

基　　金：浙江省卫生厅省部共建重点研发项目(WKJ-ZJ-2015)。

摘　　要：目的探讨烟瘾者海马、岛叶亚区与其他脑区间静息态功能连接(rs-FC)的变化及其与烟瘾之间的关系。方法自2022年1月至2024年6月向社会招募56例受试者为研究对象,其中有烟瘾者27例(烟瘾组),无烟瘾者29例(健康对照组)。烟瘾组受试者均接受多维度烟瘾量表测试。2组受试者均接受静息态功能磁共振成像(fMRI)检查。比较2组受试者一般资料、海马及岛叶各亚区与其他脑区间rs-FC的差异。采用相关性分析检验烟瘾组受试者海马及岛叶各亚区与其他脑区间rs-FC值与烟瘾量表评分的相关性。结果烟瘾组与健康对照组受试者年龄、受教育年限的差异均无统计学意义(P>0.05)。与健康对照组比较,烟瘾组受试者左侧海马内嗅皮质亚区与左侧壳核的rs-FC增强;左侧海马-杏仁核过渡亚区与左侧顶下缘角回、左侧顶上回、左侧枕中回、左侧楔前叶及左侧枕上回的rs-FC减弱;左侧后部岛叶亚区(PI)与双侧楔前叶、双侧距状裂周围皮层的rs-FC增强;左侧腹侧前部岛叶亚区与右侧缘上回、右侧颞上回、右侧中央沟盖的rs-FC增强,与双内侧额上回的rs-FC减弱;差异均有统计学意义(P<0.05)。相关性分析发现烟瘾者左侧岛叶的PI亚区与左侧楔前叶的rs-FC值与法氏烟草依赖评估量表(FTND)评分、吸烟严重度指数表(HSI)呈正相关关系(r=0.462,P=0.015;r=0.492,P=0.009);左侧岛叶的PI亚区与右侧楔前叶的rs-FC值与FTND、HSI量表评分呈正相关关系(r=0.417,P=0.031;r=0.472,P=0.013);左侧岛叶的PI亚区与右侧距状裂周围皮层的rs-FC值与FTND、HSI量表评分呈正相关关系(r=0.485,P=0.010;r=0.496,P=0.009)。结论烟瘾者海马、岛叶亚区与其他脑区间存在异常改变的rs-FC模式,且这些变化与烟瘾的严重程度及依赖程度相关。Objective To explore the alterations in resting-state functional connectivity(rs-FC)of hippocampal and insular subregions with other regions of the whole brain in nicotine addicts and their correlations with nicotine addiction.Methods A total of 56 participants,including 27 nicotine addicts and 29 healthy controls,were recruited from community from January 2022 to June 2024.Multidimensional nicotine addiction scales were performed in nicotine addiction group.Resting-state functional magnetic resonance imaging(fMRI)was performed in the 2 groups;general data and rs-FC differences between hippocampal and insular subregions with other regions of the whole brain were compared between the 2 groups.Correlations of rs-FC alterations between hippocampal and insular subregions with other regions of the whole brain with nicotine addiction scale scores in the nicotine addiction group were analyzed.Results No significant difference in age or years of education was noted between the nicotine addiction group and healthy control group(P>0.05).Compared with the healthy control group,nicotine addiction group had enhanced rs-FC between the left entorhinal cortex of the hippocampus and left putamen,attenuated rs-FC between the left hippocampal-amygdaloid transitional area and widespread regions including the left angular gyrus,left superior parietal gyrus,left middle occipital gyrus,left precuneus,and left superior occipital gyrus,enhanced rs-FC between the left posterior insular(PI)and bilateral precuneus or pericalcarine cortex,attenuated rs-FC between the left ventral anterior insula and widespread regions including the right supramarginal gyrus,right supratemporal gyrus and right central sulcus,and attenuated rs-FC between the left ventral anterior insula and bilateral medial superior frontal gyrus,with significant differences(P<0.05).Correlation analysis showed that rs-FC between the left PI and left precuneus was positively correlated with Fagerstrőm test for nicotine dependence(FTND)scores and heaviness of smoking index(HSI,

关 键 词：烟瘾 静息态功能连接 海马亚区 岛叶亚区 

分 类 号：R163[医药卫生—公共卫生与预防医学]