多环芳烃在炎症性皮肤病发生发展中的作用研究进展  

Role of polycyclic aromatic hydrocarbons in the occurrence and development of inflammatory skin diseases

作　　者：林子沅 庞天怡 武静文 靳慧 Lin Ziyuan;Pang Tianyi;Wu Jingwen;Jin Hui(Hospital of Dermatology,Chinese Academy of Medical Sciences and Peking Union Medical College,Nanjing 210042,China;Key Laboratory of Basic and Translational Research for Immune-Mediated Skin Diseases,Chinese Academy of Medical Sciences,Nanjing 210042,China;Hunan Provincial Key Laboratory of Dermatology Epigenomics,the Second Xiangya Hospital of Central South University,Changsha 410011,Hunan,China;Department of Dermatology,Xiangya Hospital,Central South University,Changsha 410011,China;Department of Dermatology,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China)

机构地区：[1]中国医学科学院北京协和医学院皮肤病医院,南京210042 [2]中国医学科学院免疫性皮肤病基础与转化研究重点实验室,南京210042 [3]中南大学湘雅二医院皮肤科医学表观基因组学湖南省重点实验室,长沙410011 [4]中南大学湘雅医院皮肤科,长沙410011 [5]上海交通大学医学院附属瑞金医院皮肤科,上海200025

出　　处：《中华皮肤科杂志》2024年第8期765-769,共5页Chinese Journal of Dermatology

基　　金：国家自然科学基金(81874253);湖南省自然科学基金(2021JJ40837);湖南省科技创新人才计划优秀博士后创新人才项目(2020RC2014);中国博士后科学基金第15批特别资助(站中)项目(2022T150742)。

摘　　要：多环芳烃(PAH)是含两个以上苯环的化合物,广泛存在于环境之中,可通过各种途径影响人体健康。以往PAH对健康影响研究多集中在其致癌性、致畸性以及对肺部疾病、心血管疾病等的影响,近年来PAH对炎症性皮肤病(尤其是银屑病、特应性皮炎和红斑狼疮)的影响日益受到重视。本文综述PAH对炎症性皮肤病的研究进展。Polycyclic aromatic hydrocarbons(PAHs)are compounds with more than two benzene rings,widely exist in the environment,and can affect human health in various ways.Previous studies on the health effects of PAHs mainly focused on their carcinogenicity,teratogenicity,and effects on pulmonary diseases,cardiovascular diseases,etc.In recent years,increasing attention has been paid to the negative influence of PAHs to inflammatory skin diseases(especially psoriasis,atopic dermatitis,and lupus erythematosus).This review summarizes recent research advances in the role of PAHs in the occurrence and development of inflammatory skin diseases.

关 键 词：多环碳氢化合物 芳香族 烟雾 颗粒物 银屑病 皮炎 特应性 红斑狼疮 皮肤 红斑狼疮 系统性 炎症性皮肤病 

分 类 号：R758.2[医药卫生—皮肤病学与性病学]