小针刀疗法联合自拟接骨活血方治疗高龄膝关节骨性关节炎  

Effect of small-needle-knife therapy combined with self-made Jiegu Huoxue prescription in the treatment of elderly patients with osteoarthritis of knee joint

作　　者：罗华[1] 王聪 林丽[2] 倪嘉纳[1] LUO Hua;WANG Cong;LIN Li;NI Jiana(Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200021,China;Pharmacy Experimental Center,Gansu University of Chinese Medicine,Lanzhou 730000,China)

机构地区：[1]上海中医药大学附属曙光医院,上海200021 [2]甘肃中医药大学生药学实验中心,兰州730000

出　　处：《吉林中医药》2024年第8期974-978,共5页Jilin Journal of Chinese Medicine

基　　金：国家自然科学基金资助项目(82174406);上海市科学技术委员会科研计划项目(22401901900)。

摘　　要：目的探讨小针刀疗法联合自拟接骨活血方治疗高龄膝关节骨性关节炎的效果。方法选取2021年11月-2023年3月本院收治的84例高龄膝关节骨性关节炎患者为研究对象,利用随机数字表法将其分为2组,观察组和对照组,各42例,对照组采用小针刀疗法治疗,观察组采用小针刀疗法联合自拟接骨活血方治疗,比较2组患者的中医证候积分、膝关节功能评分、炎症因子、骨代谢指标及临床疗效。结果治疗前,2组中医症状积分、莱氏(Lysholm)评分、血清肿瘤坏死因子-α(TNF-α)水平、白介素-6(IL-6)水平、骨特异性碱性磷酸酶(BALP)水平、胰岛素样生长因子1(IGF-1)水平、骨钙素(BGP)水平差异无统计学意义(P>0.05)。治疗后,观察组中医症状积分、TNF-α水平、IL-6水平低于对照组(P<0.05),观察组Lysholm评分、BALP水平、IGF-1水平、BGP水平高于对照组(P<0.05);观察组总有效率高于对照组(P<0.05);2组患者不良反应发生率差异无统计学意义(P>0.05)。结论小针刀疗法联合自拟接骨活血方能够有效降低患者中医证候积分,改善膝关节功能,降低疼痛程度,提高临床疗效,值得推广。Objective To investigate the effect of the small-needle-knife therapy combined with the self-made Jiegu Huoxue prescription in the treatment of the elderly patients with knee joint osteoarthritis.Methods A total of 84 elderly patients with osteoarthritis of knee joint admitted to our hospital from November 2021 to March 2023 were selected as the study subjects,and they were divided into two groups by the random number table method:an observation group(42 cases)and a control group(42 cases).The control group was treated with the small-needle-knife therapy,while the observation group was treated with the small-needle-knife therapy combined with the self-made Jiegu Huoxue prescription.The TCM syndrome scores,knee joint function scores,inflammatory factors,bone metabolism indexes and clinical efficacy of the two groups were compared.Results Before treatment,there was no statistically significant difference in the TCM symptom scores,Lysholm scores,serum tumor necrosis factor-α(TNF-α)level,interleukin-6(IL-6)level,bone specific alkaline phosphatase(BALP)level,insulin-like growth factor 1(IGF-1)level and bone gla protein(BGP)level between the two groups(P>0.05).After treatment,the TCM symptom scores,TNF-αlevel and IL-6 level were lower in the observation group than those in the control group(P<0.05),while the Lysholm scores,BALP level,IGF-1 level and BGP level were higher in the observation group than those in the control group(P<0.05).The total effective rate of the observation group was higher than that of the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The small-needle-knife therapy combined with the self-made Jiegu Huoxue prescription can effectively reduce the TCM syndrome scores of patients,improve their knee joint function,reduce the degree of pain,and improve the clinical efficacy,which is worth promoting.

关 键 词：小针刀疗法 接骨活血方 膝关节骨性关节炎 中医证候积分 膝关节功能 炎症因子 

分 类 号：R274[医药卫生—中医骨伤科学]