转化因子-β受体在A型主动脉夹层患者中的表达及对预后的影响研究  

Expression of TGFBR1 and TGFBR2 in patients with Standford type A aortic dissection and its effect on prognosis

作　　者：常冬庆[1] 叶尔买克·唐沙哈尔[1] 邵劲杰 张晓猛 买买提艾力·艾则孜[1] Chang Dongqing;Yeermaike·Tangshahaer;Shao Jinjie;Zhang Xiaomeng;MaiMaitiaili·Aizezi(Department I of cardiology in cardiac and pan-vascular medicine center,Xinjiang Uygur Autonomous Region People's Hospital,Xinjiang Urumqi 830000,China)

机构地区：[1]新疆维吾尔自治区人民医院心脏及泛血管医学诊疗中心心脏外一科,乌鲁木齐830000

出　　处：《中国体外循环杂志》2024年第4期293-297,304,共6页Chinese Journal of Extracorporeal Circulation

基　　金：新疆维吾尔自治区自然科学基金(2021D01C175);新疆维吾尔自治区人民医院院内项目(20230120)。

摘　　要：目的探究转化生长因子-β受体(TGFBR)1、TGFBR2在Standford A型主动脉夹层(STAAD)患者中的表达及对预后的影响。方法以2019年7月至2023年5月就诊于新疆维吾尔自治区人民医院的STAAD患者172例作为研究对象,根据患者术后存活情况划分为存活组(n=138)和死亡组(n=34)。对比两组患者一般临床资料及疾病特征、主动脉壁组织中TGFBR1、TGFBR2的表达水平特征。通过Spearman相关性分析及Logistic回归分析筛选STAAD患者预后不良的危险因素。通过受试者工作曲线(ROC)评价各危险因素独立及联合的预测效能。结果死亡组患者平均主动脉壁组织中TGFBR1、TGFBR2转录水平均显著低于存活组患者(P<0.05);Spearman相关性分析及多因素Logistic回归分析发现体外循环时间(OR=1.320,95%CI:1.021~1.626)、TGFBR1(OR=0.015,95%CI:0.003~0.042)、TGFBR2转录水平(OR=0.031,95%CI=0.011~0.093)均是STAAD患者预后不良的潜在危险因素,且各危险因素独立及联合预测患者预后不良效能均较高(P<0.05)。结论在STAAD患者主动脉壁组织中TGFBR1、TGFBR2转录水平均显著降低,且与患者预后具有负相关性,提示TGFBR1、TGFBR2有可能作为未来评估及预测STAAD患者预后的潜在标志物。Objective To investigate the expression of Transforming Growth Factor-βReceptors(TGFBR)1 and 2 in patients with Stanford Type A Aortic Dissection(STAAD)and their impacts on prognosis.Methods 172 patients diagnosed with STAAD were included in this study who conducted at our hospital between July 2019 and May 2023.These patients were divided into a survival group(n=138)and a death group(n=34)based on their postoperative survival status.General clinical data,disease characteristics,and the expression levels of TGFBR1 and TGFBR2 in aortic wall tissues were compared between the two groups.Spearman correlation analysis and Logistic regression analysis were employed to identify potential risk factors associated with poor prognosis in STAAD patients.Furthermore,the predictive accuracy of both independent and combined risk factors was assessed using Receiver Operating Characteristic(ROC)analysis.Results The expression levels of TGFBR1 and TGFBR2 in aortic wall tissue were significantly lower in the mortality group compared to the survival group(P<0.05).Spearman correlation analysis and multivariate Logistic regression analysis indicated that cardiopulmonary bypass duration(OR=1.320,95%CI:1.021~1.626),TGFBR1(OR=0.015,95%CI:0.003~0.042),and TGFBR2 transcription levels(OR=0.031,95%CI=0.011~0.093)were potential risk factors for poor prognosis in STAAD patients.Furthermore,both independent and combined risk factors demonstrated high predictive performance for poor prognosis(P<0.05).Conclusion The expression levels of TGFBR1 and TGFBR2 in aortic wall samples from individuals with STAAD showed notable downregulation and were inversely associated with patient outcomes,which implied that TGFBR1 and TGFBR2 could serve as promising indicators for assessing and predicting the prognosis of STAAD patients in forthcoming studies.

关 键 词：主动脉夹层 Standford A型 TGFBR 预后 

分 类 号：R543.1[医药卫生—心血管疾病]