干细胞疗法及神经调控技术在脊髓损伤中的研究进展  

Research progress on application of stem cell and neuromodulation technology in spinal cord injury

作　　者：张彩玲 兰月 马瑗锾 ZHANG Cailing;LAN Yue;MA Yuanhuan(Guangzhou Institute of Clinical Medicine,Guangzhou First People’s Hospital,the Second Affiliated Hospital,South China University of Technology,Guangzhou 510180,China;Department of Rehabilitation Medicine,Guangzhou First People’s Hospital,the Second Affiliated Hospital,South China University of Technology,Guangzhou 510180,China)

机构地区：[1]华南理工大学附属第二医院(广州市第一人民医院)临床医学研究所,广东广州510180 [2]华南理工大学附属第二医院(广州市第一人民医院)康复医学科,广东广州510180

出　　处：《广州医药》2024年第7期689-704,共16页Guangzhou Medical Journal

基　　金：广东省自然科学基金青年提升项目(2023A1515030254);广州市科技计划项目(202206010197)。

摘　　要：脊髓损伤是一种高致残性中枢神经系统疾病,目前缺乏有效的治疗措施。干细胞组织工程兴起和神经调控技术的发展,给脊髓损伤的治疗带来新的希望。目前,多项针对脊髓损伤的干细胞相关治疗项目的临床研究已在全球注册,干细胞疗法是脊髓损伤领域的研究热点,具有良好的应用前景。而神经调控技术一直在临床上脊髓损伤后的康复治疗中发挥着重要作用,特别是靶向神经调控技术近年在脊髓损伤治疗方面取得突破性进展。有研究尝试联合干细胞疗法和神经调控技术应用治疗脊髓损伤,试图取得更好的效果。本文综述了干细胞疗法和神经调控技术在脊髓损伤治疗中的研究进展,旨在探讨其作用效果、修复机制、应用前景以及面临的问题,进一步为脊髓损伤的基础研究和临床转化提供参考。Spinal cord injury is a highly disabling disease of the central nervous system without effective treatment to date.With the rise of stem cell and tissue engineering,and the breakthrough of neuromodulation technology,it brings new hope to the treatment of spinal cord injury.At present,a number of clinical studies on stem cell-related treatment projects for spinal cord injury have been registered worldwide,which has become a research hotspot.Neuromodulation technology has been playing an important role in the clinical rehabilitation of spinal cord injury.Especially,breakthroughs have been made in the treatment of spinal cord injury by targeted neuromodulation technology in recent years,which is encouraging.Some studies have attempted to combine stem cell therapy and neuromodulation technology to treat spinal cord injuries in an attempt to achieve better effect.This review summarizes the research progress of stem cell therapy and neuromodulation technology in the treatment of spinal cord injury,with the aim of discussing their effect,repair mechanisms,application prospect and various problems to face,and providing further reference for the basic research and clinical transformation of spinal cord injury.

关 键 词：脊髓损伤 干细胞 组织工程 类器官 神经调控技术 再生医学 

分 类 号：R651.2[医药卫生—外科学]