微针射频与二氧化碳点阵激光治疗面部萎缩性痤疮瘢痕的前瞻性半脸对照研究  

A prospective,split-face study of microneedle radiofrequency versus fractional CO_(2)laser in the treatment of facial atrophic acne scars

作　　者：胡雅坤 陈梅[1] 杨海晶[1] 刘俊丽[1] 王晓丹 粟倩雅 王飞[1] HU Yakun;CHEN Mei;YANG Haijing;LIU Junli;WANG Xiaodan;SU Qianya;WANG Fei(Department of Dermatology,Zhongda Hospital,Southeast University,Nanjing 210009,China)

机构地区：[1]东南大学附属中大医院皮肤科,江苏南京210009

出　　处：《临床皮肤科杂志》2024年第8期466-469,共4页Journal of Clinical Dermatology

摘　　要：目的:通过前瞻性、自身半脸对照研究,比较侵入性微针射频与超脉冲二氧化碳(CO_(2))点阵激光治疗面部萎缩性痤疮瘢痕的疗效与安全性。方法:选取26例面部萎缩性痤疮瘢痕患者,面部两侧随机分为微针射频侧与超脉冲CO_(2)点阵激光侧。治疗间隔2个月,共治疗2次,记录治疗后患者的不良反应、患者自评疼痛度及满意度。由医生通过分析治疗前、后患者面部影像数据评估疗效。结果:经过2次治疗,所有患者面部双侧痤疮瘢痕均有不同程度改善,痤疮瘢痕权重评分均下降(P<0.01)。对于V形、M形瘢痕,微针射频侧疗效优于CO_(2)点阵激光侧(P<0.05)。对于U形瘢痕,两种治疗疗效差异无统计学意义(P>0.05)。与CO_(2)点阵激光侧相比,微针射频侧治疗疼痛评分更高(P<0.01),不良反应更少。结论:微针射频与CO_(2)点阵激光均能有效改善面部萎缩性痤疮瘢痕,微针射频不良反应更少。对于U形瘢痕,两种治疗疗效相近,而对于较深的V形瘢痕和较大的M形瘢痕,微针射频疗效更显著。Objective:To compare the efficacy and safety of invasive microneedle radiofrequency(MRF)versus ultrapulsed fractional CO_(2)laser for the treatment of facial atrophic acne scars through a prospective,split-face study.Methods:Twentysix patients with facial atrophic acne scars were enrolled.Each patient randomly received invasive MRF on one half of the face,and ultrapulsed fractional CO_(2)laser on the other facial side once every two months for two sessions.Adverse reactions were recorded after treatment,and the degrees of pain and satisfaction were self-evaluated,while the efficacy was evaluated and analyzed with patients'facial imaging data by doctors.Results:All patients showed different degrees of improvement in acne scars of bilateral face and reduction inéchelle devaluation clinique descicatrices dacne(ECCA)scores(P<0.01)after two sessions of treatments.For V-and M-shaped scars,the MRF side was more effective than the fractional CO_(2) laser side(P<0.05).For U-shaped scars,the difference in efficacy between the two treatments was not significant(P>0.05).Compared with the side receiving CO_(2)fractional laser,the side receiving MRF had a lower pain score(P<0.01)and fewer adverse effects.Conclusion:MRF and ultrapulsed CO_(2)fractional laser are both effective in improving facial atrophic acne scars,while MRF shows fewer adverse reactions.For U-shaped scars,the efficacy of both treatments is similar.For deep V-shaped scars and large M-shaped scars,MRF is more effective.

关 键 词：微针射频 二氧化碳点阵激光 痤疮瘢痕 

分 类 号：R758.733[医药卫生—皮肤病学与性病学]