川芎嗪及相关制剂联合用药在脑血管病中的应用进展  

Research Progress in Application of Tetramethylpyrazine and Related Preparations in Cerebrovascular Diseases

作　　者：冯科冉 吴娅丽 杨柳青 泥文娟 李琨 纪秋如 汪彬 唐进法[1,2] 李伟霞 FENG Keran;WU Yai;YANG Liuqing;NI Wenjuan;LI Kun;JI Qiuru;WANG Bin;TANG Jinfa;LI Weixia(Department of Pharmacy,the First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450003,Henan,China;Henan Province Engineering Research Center for Clinical Application,Evaluation and Transformation of Traditional Chinese Medicine,Zhengzhou 450003,Henan,China,Henan Provincial Key Laboratory for Clinical Pharmacy of Traditional Chinese Medicine,Zhengzhou 450003,Henan,China,Henan Province Engineering Research Center of Safety Evaluation and Risk Management of Traditional Chinese Medicine,Zhengzhou 450003,Henan,China;School of Pharmacy,Henan University of Chinese Medicine,Zhengzhou 450046)

机构地区：[1]河南中医药大学第一附属医院药学部,河南郑州450003 [2]河南省中药临床应用、评价与转化工程研究中心,河南省中药临床药学中医药重点实验室,河南省中药安全评价与风险防控工程研究中心,河南郑州450000 [3]河南中医药大学药学院,河南郑州450046

出　　处：《中华中医药学刊》2024年第8期157-162,共6页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金青年科学基金项目(82004082);国家自然科学基金河南省人才培养联合基金项目(U1504827);河南省中医药拔尖人才培养项目(豫中医科教[2018]35号);河南省高校科技创新团队项目(23IRTSTHN026)。

摘　　要：随着脑血管疾病发病率的不断升高,活血化瘀类中药在保护脑血管作用方面日益成为研究热点,川芎嗪(tetramethylpyrazine,TMP)是从中药川芎中提取出来的吡嗪类活性成分,具有抗炎、免疫调节、扩张血管等多重作用。大量的体内外研究证实TMP通过保护血管内皮细胞、保护神经元、抗炎抗氧化、抗血小板聚集等方式对脑血管疾病发挥良好的保护作用。对TMP的脑血管病保护作用及其机制进行综述,并针对目前有关TMP的联合用药进行分析,以更好地明确TMP的治疗途径和作用机理,进而促进TMP研究的开展以及临床上更好地应用。With the increasing incidence of cerebrovascular diseases, Chinese medicines for promoting blood circulation and removing blood stasis have increasingly become research hotspots in protecting cerebrovascular diseases. Tetramethylpyrazine is a pyrazine active ingredient extracted from Chuanxiong(Chuanxiong Rhizoma),which has many functions such as anti-inflammation, immunoregulation and vasodilation. A large number of in vitro and in vivo studies have confirmed that ligustrazine can protect vascular endothelial cells, neurons, anti-inflammation, anti-oxidation and anti-platelet aggregation. In this paper, the cerebral vascular protective effect and its mechanism of ligustrazine were reviewed, and the current combined use of ligustrazine was analyzed, so as to better clarify the therapeutic approach and mechanism of ligustrazine, and further promote the development of ligustrazine research and better clinical application.

关 键 词：川芎嗪 吡嗪类生物碱 联合用药 脑血管疾病 

分 类 号：R282.710.7[医药卫生—中药学]