血清FGFR2、Leptin对特发性矮小症患儿的诊断价值及其水平与骨代谢指标的相关性  

Diagnostic value of serum serum FGFR2 and Leptin in children with idiopathic dwarfism and correlation of their levels with bone metabolic indices

作　　者：李丽欣 付智伟 赵胜侠 LI Lixin;FU Zhiwei;ZHAO Shengxia(Department of Genetics,Shijiazhuang Maternal and Child Health Hospital,Shijiahzuang,Hebei 050000,China;Department of Child Healthcare,Shijiazhuang Maternal and Child Health Hospital,Shijiahzuang,Hebei 050000,China)

机构地区：[1]河北省石家庄市妇幼保健院遗传科,河北石家庄050000 [2]河北省石家庄市妇幼保健院儿童保健科,河北石家庄050000

出　　处：《检验医学与临床》2024年第16期2357-2361,共5页Laboratory Medicine and Clinic

基　　金：河北省卫生健康委员会指导性科技计划项目(20221656)。

摘　　要：目的探讨血清成纤维生长因子受体2(FGFR2)、瘦素(Leptin)水平与特发性矮小症患儿骨代谢指标的相关性及其对疾病的诊断价值。方法选取2021年9月至2023年9月于该院就诊的138例特发性矮小症患儿为观察组,另选取同期于该院进行健康体检的141例健康儿童为对照组。采用酶联免疫吸附试验检测血清FGFR2、Leptin水平;采用全自动生化分析仪检测25-羟基维生素D[25-(OH)D]、Ⅰ型前胶原氨基酸前肽(PⅠNP)、骨钙素(OC)、骨特异性碱性磷酸酶(BAP)等骨代谢指标水平;采用Pearson相关分析特发性矮小症患儿血清FGFR2、Leptin水平与骨代谢指标水平的相关性;采用多因素Logistic回归分析影响特发性矮小症发病的因素;绘制受试者工作特征(ROC)曲线分析血清FGFR2、Leptin单独及联合检测对特发性矮小症的诊断价值。结果观察组体质量、身高及25-(OH)D、PⅠNP、OC、BAP、FGFR2、Leptin水平显著低于对照组,性发育状态Ⅱ~Ⅴ期患儿比例显著高于对照组,差异均有统计学意义(P<0.05)。Pearson相关性分析结果显示,特发性矮小症患儿血清FGFR2、Leptin水平与25-(OH)D、PⅠNP、OC、BAP水平均呈正相关(P<0.05)。多因素Logistic回归分析结果显示,FGFR2、Leptin水平升高是特发性矮小症发病的保护因素(P<0.05)。ROC曲线结果显示,血清FGFR2、Leptin单独及联合诊断特发性矮小症的曲线下面积分别为0.834、0.851、0.914。结论特发性矮小症患儿血清FGFR2、Leptin水平均较低,且二者均与骨代谢指标显著相关,推测其在诊断特发性矮小症中具有一定价值。Objective To explore the correlation between serum levels of fibroblast growth factor receptor 2(FGFR2)and Leptin and bone metabolism indices in children with idiopathic dwarfism,and their diagnostic value.Methods A total of 138 children with idiopathic dwarfism who enrolled in the hospital from September 2021 to September 2023 were collected as observation group,while 141 healthy children who underwent health checkups in the hospital during the same period were selected as the control group.Enzyme-linked immunosorbent assay was applied to detect serum levels of FGFR2 and Leptin;the automatic biochemistry analyzer was used to detect the levels of bone metabolism indices,including 25-hydroxyvitamin D,typeⅠprecollagen amino acid prepeptide(PⅠNP),osteocalcin(OC)and bone-specific alkaline phosphatase(BAP);Pearson correlation analysis was applied to examine the correlation between serum FGFR2 and Leptin levels and bone metabolism indices levels in children with idiopathic dwarfism;multivariate Logistic regression was applied to analyze the factors influencing the development of idiopathic dwarfism;receiver operator characteristic(ROC)curve was plotted to analyze the diagnostic value of serum FGFR2 and Leptin alone and in combination for idiopathic dwarfism.Results The body mass,height and levels of 25-(OH)D,PⅠNP,OC,BAP,FGFR2 and Leptin in the observation group were obviously lower than those in the control group,and the proportion of sexual development stageⅡ-Ⅴwas greatly higher than that in the control group,with statistically significant differences(P<0.05).Pearson correlation analysis results showed that the serum levels of FGFR2 and Leptin in children with idiopathic dwarfism were positively correlated with 25-(OH)D,PⅠNP,OC,BAP,FGFR2 and Leptin levels(P<0.05).Multivariate Logistic regression analysis results showed that elevated FGFR2 and Leptin levels were protective factors for the development of idiopathic dwarfism(P<0.05).ROC curves results showed that the area under the curve for the diagnosis of

关 键 词：特发性矮小症 儿童 成纤维生长因子受体2 瘦素 骨代谢指标 诊断 

分 类 号：R446.11[医药卫生—诊断学]