Serological Investigation into the Infected Genotypes of Patients with Japanese Encephalitis in the Coastal Provinces of China  

作　　者：Weijia Zhang Jierong Zhao Qikai Yin Shenghui Liu Ruichen Wang Shihong Fu Fan Li Ying He Kai Nie Guodong Liang Songtao Xu Guang Yang Huanyu Wang 

机构地区：[1]National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases,National Institute for Viral Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing 102206,China [2]School of Basic Medicine and Public Health,Jinan University,Guangzhou 510000,Guangdong,China

出　　处：《Biomedical and Environmental Sciences》2024年第7期716-725,共10页生物医学与环境科学（英文版）

基　　金：supported by the National Key Research and Development Program[2022YFC2302700].

摘　　要：Objective Genotypes(G)1,3,and 5 of the Japanese encephalitis virus(JEV)have been isolated in China,but the dominant genotype circulating in Chinese coastal areas remains unknown.We searched for G5 JEV-infected cases and attempted to elucidate which JEV genotype was most closely related to human Japanese encephalitis(JE)in the coastal provinces of China.Methods In this study,we collected serum specimens from patients with JE in three coastal provinces of China(Guangdong,Zhejiang,and Shandong)from 2018 to 2020 and conducted JEV cross-neutralization tests against G1,G3,and G5.Results Acute serum specimens from clinically reported JE cases were obtained for laboratory confirmation from hospitals in Shandong(92 patients),Zhejiang(192 patients),and Guangdong(77 patients),China,from 2018 to 2020.Seventy of the 361 serum specimens were laboratory-confirmed to be infected with JEV.Two cases were confirmed to be infected with G1 JEV,32 with G3 JEV,and two with G5 JEV.Conclusion G3 was the primary infection genotype among JE cases with a definite infection genotype,and the infection caused by G5 JEV was confirmed serologically in China.

关 键 词：Japanese encephalitis virus Serological investigation Plaque reduction neutralization test Cross-neutralization test GENOTYPE 

分 类 号：R512.32[医药卫生—内科学]