血液灌流治疗对老年重度急性有机磷农药中毒患者血清CHE、DA、TGF-β_(1)及TNF-α水平的影响  

Effects of hemoperfusion on serum CHE,DA,TGF-β_(1) and TNF-αlevels in elderly patients with severe acute organophosphorus pesticide poisoning

作　　者：王雪琪 安家瑶 WANG Xueqi;AN Jiayao(Yangling Demonstration Zone Hospital,Xianyang 712100,China)

机构地区：[1]杨凌示范区医院,陕西咸阳712100

出　　处：《临床医学研究与实践》2024年第23期54-57,共4页Clinical Research and Practice

摘　　要：目的分析血液灌流治疗老年重度急性有机磷农药中毒患者的有效性及安全性。方法选择我院2020年1月至12月收治的40例老年重度急性有机磷农药中毒患者作为研究对象,以治疗方案将其分为常规组和观察组,各20例。常规组给予常规对症治疗,观察组在常规组基础上给予血液灌流治疗。比较两组的治疗效果。结果观察组的治疗总有效率显著高于常规组(P<0.05)。观察组的阿托品总用量少于常规组,昏迷持续时长、入组至胆碱酯酶(CHE)活性恢复时间及住院时长显著短于常规组(P<0.05)。治疗后,观察组的CHE、多巴胺(DA)及γ干扰素(IFN-γ)水平高于常规组,转化生长因子-β_(1)(TGF-β_(1))、肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)水平低于常规组(P<0.05)。观察组的并发症总发生率显著低于常规组(P<0.05)。结论血液灌流治疗老年重度急性有机磷农药中毒患者可取得理想的综合疗效与较高的治疗安全性。Objective To analyze the efficacy and safety of hemoperfusion in the treatment of elderly patients with severe acute organophosphorus pesticide poisoning.Methods A total of 40 elderly patients with severe acute organophosphorus pesticide poisoning admitted in our hospital from January to December 2020 were selected as the research objects.The patients were divided into conventional group and observation group according to the treatment plan,with 20 cases in each group.The conventional group was given routine symptomatic treatment,and the observation group was given hemoperfusion treatment on the basis of the conventional group.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was significantly higher than that in the conventional group(P<0.05).The total dosage of atropine in the observation group was less than that in the conventional group,and the duration of coma,the recovery time of cholinesterase(CHE)activity and the length of hospitalization were significantly shorter than those in the conventional group(P<0.05).After treatment,the levels of CHE,dopamine(DA)and interferon-γ(IFN-γ)in the observation group were higher than those in the conventional group,and the levels of transforming growth factor-β_(1)(TGF-β_(1)),tumor necrosis factor-α(TNF-α)and interleukin-1β(IL-1β)were lower than those in the conventional group(P<0.05).The total incidence of complications in the observation group was significantly lower than that in the conventional group(P<0.05).Conclusion Hemoperfusion in the treatment of elderly patients with severe acute organophosphorus pesticide poisoning can achieve ideal comprehensive efficacy and high treatment safety.

关 键 词：老年 重度急性有机磷农药中毒 血液透析 血液灌流 

分 类 号：R595.4[医药卫生—内科学]