虎杖对湿热证2型糖尿病患者的临床疗效  

Clinical effects of Polygonum cuspidatum on patients with type 2 diabetes mellitus of Dampness-Heat Pattern

作　　者：徐媛颖 孔稳稳 尹宏萍 张会会 蔡兴华 徐碧林[1] 沙雯君 雷涛[1] XU Yuan-ying;KONG Wen-wen;YIN Hong-ping;ZHANG Hui-hui;CAI Xing-hua;XU Bi-lin;SHA Wen-jun;LEI Tao(Department of Endocrinology,Putuo Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200062,China;Clinical College of Putuo Center,Anhui Medical University,Shanghai 200062,China;Chengdu University of Traditional Chinese Medicine,Chengdu 610000,China)

机构地区：[1]上海中医药大学附属普陀医院内分泌科,上海200062 [2]安徽医科大学上海普陀中心临床学院,上海200062 [3]成都中医药大学,四川成都610000

出　　处：《中成药》2024年第8期2596-2600,共5页Chinese Traditional Patent Medicine

基　　金：国家自然科学基金面上基金资助项目(81774083);上海市普陀区卫生健康系统科技创新项目(ptkwws202003);上海市普陀区临床特色专科(2020tszk01);上海市医学重点专科(ZK2019B16);上海市卫生健康委员会科研课题(20204Y0154);上海市卫健委课题(202240309)。

摘　　要：目的探讨虎杖对湿热证2型糖尿病患者的临床疗效。方法140例患者随机分为对照组和观察组,每组70例,对照组给予常规治疗,观察组在对照组基础上加用虎杖颗粒,疗程8周。检测体质量、BMI、血糖指标(FBG、2 h PG、HbA_(1C)、GA)、血脂指标(TC、TG、HDL-C、LDL-C、ApoA-I、ApoB、ApoA、ApoE、sdLDL-C)、肝功能指标(ALT、AST)、脂肪肝程度、TyG、HSI、中医证候评分和疗效变化。结果观察组中医证候总有效率高于对照组(P<0.01),脂肪肝程度更轻(P<0.01)。治疗后,观察组体质量、BMI、FBG、GA、TG、ApoE、TyG、HSI、ALT、中医证候评分降低(P<0.05,P<0.01),并且2 h PG、TyG、HSI、ALT、中医证候评分低于对照组(P<0.05,P<0.01)。结论虎杖可改善湿热证2型糖尿病患者糖脂代谢紊乱,值得临床推广应用。AIM To explore the clinical effects of Polygonum cuspidatum Sieb.et Zucc.on patients with type 2 diabetes mellitus of Dampness-Heat Pattern.METHODS One hundred and forty patients were randomly assigned into control group(70 cases)for 8-week intervention of conventional treatment,and observation group(70 cases)for 8-week intervention of both P.cuspidatum granules and conventional treatment.The changes in body weight,BMI,blood glucose indices(FBG,2 h PG,HbA_(1C),GA),blood lipid indices(TC,TG,HDL-C,LDL-C,ApoA-I,ApoB,ApoA,ApoE,sdLDL-C),liver function indices(ALT,AST),fatty liver progression,TyG,HSI,TCM syndrome score and effects were detected.RESULTS The observation group demonstrated higher total effective rates of TCM syndromes than the control group(P<0.01),along with slighter fatty liver progression(P<0.01).After the treatment,the observation group displayed decreased body weight,BMI,FBG,GA,TG,ApoE,TyG,HSI,ALT and TCM syndrome score(P<0.05,P<0.01),and 2 h PG,TyG,HSI,ALT,TCM syndrome score were lower than those in the control group(P<0.05,P<0.01).CONCLUSION For the patients with type 2 diabetes mellitus of Dampness-Heat Pattern,P.cuspidatum can improve glucose and lipid metabolism disorders,which is worthy of clinical popularization and application.

关 键 词：虎杖 常规治疗 2型糖尿病 湿热证 

分 类 号：R287[医药卫生—中药学]