乙型肝炎病毒相关肝内胆管细胞癌的研究进展  

Progress of hepatitis B virus-associated intrahepatic cholangiocarcinoma

作　　者：刘天府[1] 李光明[1] 张岭漪[1] Liu Tianfu;Li Guangming;Zhang Lingyi(Department of Hepatology,Lanzhou University Second Hosipital,Lanzhou 730030,China)

机构地区：[1]兰州大学第二医院肝病科,兰州730030

出　　处：《肿瘤研究与临床》2024年第7期546-549,共4页Cancer Research and Clinic

基　　金：甘肃省教育科技创新项目(2022B-047);兰州大学第二医院“萃英科技创新”计划(CY2021-QN-A18)。

摘　　要：肝内胆管细胞癌(ICC)发病率低,恶性程度高且预后差。在我国,乙型肝炎病毒(HBV)相关ICC是最常见的ICC亚型,且其发病率呈上升趋势。HBV相关ICC的发病机制和临床特征不同于其他类型,近年来靶向治疗的应用为患者带来了更显著的生存获益。文章就HBV相关ICC发生的主要机制、患者临床特征及治疗的最新研究进展进行综述。Intrahepatic cholangiocarcinoma(ICC)is characterized with low incidence,high malignancy and poor prognosis.In China,hepatitis B virus(HBV)-associated ICC is the most common subtype of ICC and its incidence rate is on the rise.The pathogenesis and clinical characteristics of HBV-associated ICC are different from other types of ICC.In recent years,the targeted therapy has brought significant survival benefits for patients.This article reviews the pathogenesis of HBV-associated ICC and the latest research progress of the clinical characteristics and treatments of patients.

关 键 词：肝炎病毒 乙型 肝内胆管癌 感染 治疗 

分 类 号：R512.62[医药卫生—内科学] R735.8[医药卫生—临床医学]