早产儿动脉导管未闭不同药物治疗方案的研究进展  

Research progress on different drug treatments for patent ductus arteriosus in preterm

作　　者：王乐瑶 徐思媛 高翔羽[1] Wang Leyao;Xu Siyuan;Gao Xiangyu(Department of Neonatology,Xuzhou Central Hospital(Xuzhou Clinical College of Xuzhou Medical University),Xuzhou 221009,China)

机构地区：[1]徐州市中心医院(徐州医科大学徐州临床学院)新生儿科,徐州221009

出　　处：《中华实用儿科临床杂志》2024年第8期633-636,共4页Chinese Journal of Applied Clinical Pediatrics

基　　金：江苏省研究生实践创新计划(SJCX22_1286);江苏省妇幼健康科研项目(F202063);江苏省妇幼保健协会科研项目(FYX201902);徐州市科技局重点研发计划(KC20069)。

摘　　要：早产儿血流动力学显著异常动脉导管未闭(hsPDA)的最佳药物治疗方案仍存争议。有严重脑室内出血高风险的超早产儿或超低出生体重儿可考虑预防性静脉注射吲哚美辛;以下情况可选择不给予药物干预的期待管理:无症状、胎龄≥28周或出生体重≥1000 g早产儿出生7~14 d内、影响hsPDA自发闭合的危险因素较少等。期待管理失败,可给予药物干预,推荐口服高剂量布洛芬、口服对乙酰氨基酚和口服标准剂量布洛芬等。The optimal drug treatment for preterm infants with hemodynamically significant patent ductus arteriosus(hsPDA)is still controversial.The prophylactic intravenous injection of indomethacin can be considered for extremely preterm infants or extremely low birth weight infants with a high risk of severe intraventricular hemorrhage.The expectant management without drug intervention can be chosen in the following situations:asymptomatic;preterm infants with gestational age≥28 weeks or birth weight≥1000 g are born within 7-14 days;and there are few risk factors affecting spontaneous closure of hsPDA.The drug intervention can be given if the expectant management fails.Oral administration of high-dose Ibuprofen,Acetaminophen and standard-dose Ibuprofen are recommended.

关 键 词：动脉导管未闭 药物治疗 婴儿 早产 

分 类 号：R722.6[医药卫生—儿科]