固相萃取-高效液相色谱-三重四级杆质谱联用法测定一次性静脉留置针中痕量双酚A的方法优化  

Optimization of Solid Phase Extraction-high Performance Liquid Chromatography-triple Quadrupole Mass Spectrometry for Determination of Trace Amounts of Bisphenol A in Indwelling Needles

作　　者：朱雪飞 程怡洁 王紫芸 苟彦彦 许静远 刘慧 Zhu Xuefei;Cheng Yijie;Wang Ziyun;Gou Yanyan;Xu Jingyuan;Liu Hui(Yangzhou Center for Food and Drug Control,Jiangsu,225000;Changshu Hospital Affi liated to Suzhou University,Jiangsu,215500;School of Biology and Food Engineering,Changshu Institute of Technology,Jiangsu,215500)

机构地区：[1]扬州市食品药品检验检测中心,江苏225000 [2]苏州大学附属常熟医院,江苏215500 [3]常熟理工学院生物与食品工程学院,江苏215500

出　　处：《当代化工研究》2024年第15期78-80,共3页Modern Chemical Research

基　　金：江苏省市场监督管理局科技计划项目“静脉留置针中双酚A的残留情况及静脉注射液对静脉留置针中双酚A迁出影响的研究”(项目编号:KJ21125070)。

摘　　要：目的:通过优化固相萃取(SPE)等各项参数,建立固相萃取纯化静脉留置针中双酚A(BPA)含量样品的处理方法。方法:样品经固相萃取柱净化并富集BPA,采用液质联用法(HPLC-MS/MS)测定。结果:建立了一种HPLC-MS/MS法测定静脉留置针中BPA含量样品的固相萃取方法。结论:该方法条件优良,可有效纯化和富集静脉留置针中的痕量BPA,便于准确测定样品中BPA的含量。Objective:To establish a method for extraction-purification-quantitative determination of bisphenol A(BPA)in indwelling needles by optimizing the parameters of solid phase extraction(SPE).Methods:BPA was purified and enriched by SPE column and determined by HPLCMS/MS.Results:A solid phase extraction method was established for the determination of BPA content in intravenous catheters using HPLC-MS/MS.Conclusion:The method is suitable for the extraction and enrichment of BPA from indwelling needles and the determination of target compounds in samples.

关 键 词：双酚A 静脉留置针 固相萃取 液质联用法 

分 类 号：O657[理学—分析化学]