Glucose-sensitive Membrane with PBA-based Contraction-type Linear Polymer as Chemical Valves Prepared by Surface Grafting  

作　　者：Chun-Peng Zhang Si-Jia Gao Ying Luo Lei Zou Yong-Jun Zhang 

机构地区：[1]State Key Laboratory of Separation Membranes and Membrane Processes,School of Material Science and Engineering,Tiangong University,Tianjin 300387,China [2]State Key Laboratory of Separation Membranes and Membrane Processes,School of Pharmaceutical Sciences,Tiangong University,Tianjin 300387,China [3]Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases,Institute of Hepatobiliary Disease,Nankai University Affiliated Third Center Hospital,Tianjin 300170,China [4]Cangzhou Institute of Tiangong University,Cangzhou 061000,China

出　　处：《Chinese Journal of Polymer Science》2024年第8期1067-1076,共10页高分子科学（英文版）

基　　金：financially supported by the National Natural Science Foundation of China(Nos.52033004,52273109 and22275137);Cangzhou Institute of Tiangong University(No.TGCYY-F-0203);Hebei Province Natural Science Foundation(No.E2023110007)。

摘　　要：Glucose-sensitive membrane has potential application in self-regulating insulin release.Phenylboronic acid(PBA)is a well-known glucose reporter.Unfortunately,most PBA-based glucose-sensitive materials are expansion-type,which are not suitable as chemical valves in membrane pores for self-regulating insulin release.According to a new glucose-sensitive mechanism,we synthesized PBA-based contraction-type glucose-sensitive liner polymer and microgels.Herein,a glucose-sensitive membrane was prepared by grafting PBA-based contraction-type glucose-sensitive linear polymer on the membrane surface.Through adjusting the chain length and chain density,the glucose-sensitivity of the membrane was optimized.The membrane can reversibly regulate insulin release at physiologically relevant glucose concentrations in simulates body fluids and fetal bovine serum.The membrane also has good stability,anti-fouling and biocom patibility.It has potential application in selfregulating insulin release.

关 键 词：Phenylboronic acid Glucose-sensitive MEMBRANE Surface grafting Insulin 

分 类 号：R318.08[医药卫生—生物医学工程] TQ317[医药卫生—基础医学] TB383.2[化学工程—高聚物工业]