Shear-thinning Catechol-modified Chitosan Hydrogel Loaded with Silver Nanoparticles for Endoscopic Submucosal Dissection  

作　　者：Wen-Jun Feng Yan-He Wu Xiao-Yang Liu Zheng-Ke Wang 

机构地区：[1]MOE Key Laboratory of Macromolecular Synthesis and Functionalization,Department of Polymer Science and Engineering,Zhejiang University,Hangzhou 310058,China

出　　处：《Chinese Journal of Polymer Science》2024年第8期1147-1155,共9页高分子科学（英文版）

基　　金：financially supported by Science Fund for Distinguished Young Scholars of Zhejiang Province(No.LR20E030004);the National Natural Science Foundation of China(No.51873187);National Basic Research Program of China(No.2018YFC1004803)。

摘　　要：Shear-thinning hydrogels have emerged for endoscopic submucosal dissection,while wound intervention after surgery has rarely been mentioned.Herein,a catechol-modified chitosa n hydrogel with shear-thinning property was developed for simultaneously facilitating endoscopic submucosal dissection and postoperative wound healing.Benefiting from the shear-thinning and self-healing characteristics,the asprepared hydrogel showed easily endoscopic injectability.It also performed very well as submucosal cushion,which could remain above 70%after injection for 120 min in ex vivo porcine large intestine model.In fact,the cushion height of normal saline dramatically decreased to 46%of the initial height at 30 min.Ag nanoparticles encapsulated into the network endowed the hydrogel with almost reached 100%antibacterial effect against E.coli and S.aureus.The hemolysis ratio of the hydrogel was calculated to be as low as 0.8%.Combined with good hemocompatibility and cytocompatibility,the as-prepared hydrogel displayed much higher in vivo wound closu re and healing efficacy than normal saline.These results demonstrated the superiority of the shear-thinning chitosan hydrogel in facilitating clinical endoscopic submucosal dissection surgery.

关 键 词：Shear-thinning hydrogel Endoscopic mucosal dissection Wound healing Catechol-modified chitosan Silver nanoparticles 

分 类 号：TQ427.26[化学工程] R318.08[医药卫生—生物医学工程]