可降解镁基金属引导骨再生膜的研究现状与展望  

Research status and prospects of biodegradable magnesium-based metal guided bone regeneration membranes

作　　者：陈良伟 韩建民 郭传瑸[1,2] Chen Liangwei;Han Jianmin;Guo Chuanbin(Dept.of Oral and Maxillofacial Surgery,Peking University School and Hospital of Stomatology,Beijing 100081,China;National Center of Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical Devices,Beijing 100081,China;Dept.of Key Laboratory,Peking University School and Hospital of Stomatology,Beijing 100081,China)

机构地区：[1]北京大学口腔医学院·口腔医院口腔颌面外科,北京100081 [2]国家口腔医学中心·国家口腔疾病临床医学研究中心·口腔生物材料和数字诊疗装备国家工程研究中心,北京100081 [3]北京大学口腔医学院·中心实验室,北京100081

出　　处：《华西口腔医学杂志》2024年第4期415-425,共11页West China Journal of Stomatology

基　　金：国家重点研发计划(2021YFC2400703);国家自然科学基金(52171234);北京市科技计划(Z211100002921066);北京大学口腔医院国家临床重点专科科技成果转化支持项目(PKUSSNKP-Т202104)。

摘　　要：可降解镁基金属引导骨再生(GBR)膜具有良好的机械性能、生物降解性和生物促成骨性能,是治疗颌面部骨缺损的理想植入物。本文对镁基金属引导骨再生膜的现状和未来的研究趋势进行阐述。首先介绍了镁基金属的研究历史及应用领域,随后从镁基金属GBR膜的机械性能、生物相容性和促成骨性能及其机制方面介绍了镁基金属制备GBR膜的应用优势,最后对当前镁基金属GBR膜的局限性及在口腔医学中的应用和展望进行介绍。镁基金属GBR膜在基础和转化研究方面都取得了重要的进展,为治疗口腔颌面部的骨缺损奠定了重要的基础。Biodegradable magnesium-based metal guided bone regeneration(GBR)membranes possess excellent mechanical properties,biodegradability,and osteopromotive capabilities,making them ideal implants for the treatment of maxillofacial bone defects.This review summarizes the current status and future research trends related to magnesiumbased GBR membranes.First,the research history and application fields of magnesium-based metals are introduced,and the advantages of the use of magnesium-based materials for GBR membranes,including their mechanical properties,biocompatibility,osteopromotive performance,and underlying mechanisms are discussed.Finally,this review addresses the current limitations of magnesium-based GBR membranes and their applications and prospects in the field of dentistry.In conclusion,considerable advancements have been in fundamental and translational research on magnesium-based GBR membranes,which lays a crucial foundation for the treatment of maxillofacial bone defects.

关 键 词：镁基金属 引导骨再生膜 降解 骨再生 临床转化 

分 类 号：R318.08[医药卫生—生物医学工程]