丹栀逍遥散加味联合生活方式干预治疗女童中枢性性早熟阴虚火旺证37例临床观察  

Clinical observation on 37 cases of central precocious puberty in girls with flaring of fire due to yin deficiency syndrome treated by modified Danzhi Xiaoyao San(丹栀逍遥散)combined with lifestyle intervention

作　　者：陈波[1] 甘霞[2] 刘青 CHEN Bo;GAN Xia;LIU Qing(Department of Pediatrics,The First Affiliated Hospital of Shihezi University,Shihezi,Xinjiang,832000,China;Department One of Traditional Chinese Medicine,The First Affiliated Hospital of Shihezi University,Shihezi,Xinjiang,832000,China;School of Medicine,Shihezi University,Shihezi,Xinjiang,832000,China)

机构地区：[1]石河子大学第一附属医院儿科,新疆石河子832000 [2]石河子大学第一附属医院中医一科,新疆石河子832000 [3]石河子大学医学院,新疆石河子832000

出　　处：《中医儿科杂志》2024年第4期67-70,共4页Journal of Pediatrics of Traditional Chinese Medicine

摘　　要：目的观察丹栀逍遥散加味联合生活方式干预治疗女童中枢性性早熟(CPP)阴虚火旺证的临床疗效。方法选取2021年2月至2023年2月在石河子大学第一附属医院儿科收治的65例CPP女童作为研究对象,按是否接受中药治疗分为对照组28例和治疗组37例。对照组给予生活方式干预,治疗组在对照组生活方式干预的基础上给予丹栀逍遥散加味治疗,2组均治疗3个月后统计临床疗效。结果治疗前2组乳核大小、子宫长径、卵巢容积比较,差异均无统计学意义(P>0.05),具有可比性;治疗后2组乳核大小、子宫长径及卵巢容积均明显缩小,与同组治疗前比较,差异均有统计学意义(P<0.05),且治疗组缩小更显著(P<0.05)。治疗前2组黄体生成素(LH)和卵泡刺激素(FSH)水平比较,差异均无统计学意义(P>0.05),具有可比性;治疗后治疗组LH、FSH水平显著下降,与同组治疗前及对照组治疗后比较,差异均有统计学意义(P<0.05),对照组治疗后LH、FSH水平有所下降,但差异无统计学意义(P<0.05)。对照组总有效率为60.71%(17/28),治疗组为86.49%(32/37),2组比较,差异有统计学意义(P<0.05)。结论丹栀逍遥散加味联合生活方式干预治疗女童CPP阴虚火旺证,可有效改善临床症状,降低性激素水平,疗效显著,值得临床推广应用。Objectivee To observe the clinical efficacy of modified Danzhi Xiaoyao San combined with lifestyle intervention in the treatment of central precocious puberty(CPP)in girls.Methods 65 CPP girls admitted to the Department of Pediatrics at the First Affiliated Hospital of Shihezi University from February 2021 to February 2023 were selected as the study subjects.They were divided into a control group of 28 cases and a treatment group of 37 cases based on whether they received traditional Chinese medicine treatment.The control group received lifestyle intervention,while the treatment group received modified Danzhi Xiaoyao San treatment on the basis of lifestyle intervention in the control group.After 3 months of treatment,both groups were statistically analyzed for clinical efficacy.Results There was no statistically significant difference(P>0.05)in the size of the breast nucleus,uterine diameter,and ovarian volume between the two groups before treatment,indicating comparability.After treatment,the size of the breast nucleus,uterine diameter,and ovarian volume in both groups significantly decreased.Compared with the same group before treatment,the differences were statistically significant(P<0.05),and the reduction was more significant in the treatment group(P<0.05).There was no statistically significant difference(P>0.05)in the levels of luteinizing hormone(LH)and follicle stimulating hormone(FSH)between the two groups before treatment,indicating comparability.After treatment,the levels of LH and FSH in the treatment group significantly decreased.Compared with the same group before treatment and the control group after treatment,the differences were statistically significant(P<0.05).The levels of LH and FSH in the control group decreased after treatment,but the difference was not statistically significant(P<0.05).The total effective rate of the control group was 60.71%(17/28),while that of the treatment group was 86.49%(32/37).The dfference between the two groups was statistically significant(P<0.05).Conclusion Modif

关 键 词：中枢性性早熟 女童 阴虚火旺证 丹栀逍遥散 临床观察 

分 类 号：R725.8[医药卫生—儿科]