良性前列腺增生患者血液炎症指标和PSA的表达研究  

Expressions of Blood Inflammatory Markers and PSA in Patients with Benign Prostatic Hyperplasia

作　　者：邹超世 谢钰玲 刘燕萍 刘康海 袁育林[3] 廖春华[1] 李明强 陈伊 林婵 ZOU Chaoshi;XIE Yuling;LIU Yanping;LIU Kanghai;YUAN Yulin;LIAO Chunhua;LI Mingqiang;CHEN Yi;LIN Chan(The First People’s Hospital of Yulin,Sixth Affiliated Hospital of Guangxi Medical University,Yulin 537000,China;The Maternal and Child Health Care Hospital of Yulin,Yulin 537000,China;Department of Laboratory,the People’sHospital of Guangxi Zhuang Autonovous Region,Guangxi Academy of Medical Sciences,Nanning 537021,China)

机构地区：[1]玉林市第一人民医院广西医科大学第六附属医院,广西玉林537000 [2]玉林市妇幼保健院,广西玉林537000 [3]广西医学科学院广西壮族自治区人民医院检验科,广西南宁530021

出　　处：《标记免疫分析与临床》2024年第7期1242-1247,共6页Labeled Immunoassays and Clinical Medicine

基　　金：国家重点研发计划-老年前列腺增生的综合防控技术研究与精准风险评估和个体化防治措施应用示范(编号:2021YFC2009300,2021YFC2009301);广西壮族自治区卫生健康委员会(编号:Z-A20220039)。

摘　　要：目的通过检测C反应蛋白(C-reaction protein,CRP)、超敏CRP(high sensitive C-reaction protein,hs-CRP)、白细胞介素6(interleukin-6,IL-6)、唾液腺淀粉酶A(salivary gland amylase A,SAA)、白细胞计数(white blood cell count,WBC)、总前列腺特异性抗原(total prostate specific antigen,TPSA)和游离前列腺特异性抗原(free prostate specific antigen,FPSA)在单纯前列腺增生(benign prostatic hyperplasia,BPH)与合并组织学炎症的BPH患者血液中浓度,探讨炎症与BPH的发生发展的关系。方法收集自2022年6月至2023年8月间在玉林市第一人民医院收治的134例病理诊断为BPH患者作为研究对象,根据术后病理结果是否合并组织学炎症分为单纯组和炎症组,以50例同期健康体检者作为对照组,比较3组对象的CRP、hs-CRP、IL-6、SAA、WBC计数、TPSA、FPSA及前列腺体积(prostate volume,PV)间的差异,Spearman法分别分析BPH患者PV和TPSA与CRP、hs-CRP、IL-6、SAA、WBC计数、TPSA、FPSA的关系。结果与对照组相比,BPH单纯组和炎症组患者PV增大,血液指标CRP、hs-CRP、IL-6、SAA、TPSA及FPSA水平明显升高,差异均有统计学意义(P<0.01)。与单纯BPH组比较,BPH炎症组PV体积增大,TPSA、FPSA、CRP、hs-CRP、SAA、IL-6水平升高,差异有统计学意义(P<0.05)。而WBC计数在3组对象的相互比较中差异不明显,无统计学意义(P>0.05)。BPH患者血液指标CRP、hs-CRP、IL-6、SAA、WBC计数、TPSA、FPSA与PV呈正相关(P<0.01),CRP、hs-CRP、IL-6、SAA、FPSA与TPSA正相关(P<0.01)。结论血液指标CRP、hs-CRP、IL-6、SAA、TPSA及FPSA水平在3组间差异具有统计学意义,和BPH患者PV呈正相关,可能在前列腺增生和发展中起重要作用,作为良性前列腺增生发生的关键预测因素,有待继续深入研究。Objective To detect expressions of C-reactive protein(CRP),high sensitive C-reaction protein(hs-CRP),Interleukin-6(IL-6),Salivary gland amylase A(SAA),White blood cell count(WBC),total prostate specific antigen(TPSA)and free prostate specific antigen(FPSA)in blood samples of patients with simple benign prostatic hyperplasia(BPH)and BPH combined with prostatitis,and to further evaluate the effect of inflammation on the development and progression of BPH.Methods 134 patients with prostatic hyperplasia from June,2022 to August,2023 in our hospital were collected as study group,and these patients were divided into a simple group and an inflammation group according to whether there was histological inflammation based on pathological check results.Fifty healthy men were also selected as the control group.Levels of serum CRP,hs-CRP,IL-6,SAA,TPSA,FPSA,white blood cell count and prostate volume(PV)were compared among the three groups.Spearman method was used to analyze associations between PV and CRP,hs-CRP,IL-6,SAA,WBC count,TPSA,and FPSA,as well as TPSA and CRP,hs-CRP,IL-6,SAA,WBC count,FPSA in BPH patients.Results Compared with the control group,PV of the simple BPH patients and the inflammation BPH patients increased,and levels of CRP,hs-CRP,IL-6,SAA,TPSA and FPSA increased significantly(P<0.01).Compared with simple BPH patients,PV volume of BPH patients with inflammation was increased,and levels of TPSA,FPSA,CRP,hs-CRP,SAA and IL-6 were also significantly increased(P<0.01).However,there was no significant difference in WBC among the three groups(P>0.05).Levels of CRP,hs-CRP,IL-6,SAA,WBC,TPSA and FPSA were positively correlated with PV in BPH patients(P<0.01).CRP,hs-CRP,IL-6,SAA and FPSA were positively correlated with TPSA(P<0.01).Conclusion Levels of CRP,hs-CRP,IL-6,SAA,TPSA and FPSA are significantly different among the three groups,and positively correlated with PV in BPH patients,which could play an important role in the development and progression of prostatic hyperplasia.As a key predictor of the occurrence of

关 键 词：良性前列腺增生 组织学炎症 前列腺特异性抗原 白细胞介素-6 

分 类 号：R697.32[医药卫生—泌尿科学]