血清HIF-1α、LP(a)、VEGF、LP-PLA2水平与冠心病病情的相关性研究  

The Relationship Between Serum HIF-1α,LP(a),VEGF,LP-PLA2 Levels and Coronary Heart Disease

作　　者：沈丽娟 王兴荣 杜晓峰 孙志刚 SHEN Lijuan;WANG Xingrong;DU Xiaofeng;SUN Zhigang(Shanghai Jinshan District Integrated Traditional Chinese and Western Medicine Hospital,Shanghai 201501,China)

机构地区：[1]上海市金山区中西医结合医院,上海201501

出　　处：《标记免疫分析与临床》2024年第7期1254-1258,共5页Labeled Immunoassays and Clinical Medicine

基　　金：金山区中西医结合医院院内课题(编号:2021-5)。

摘　　要：目的分析血清低氧诱导因子-1α(HIF-1α)、脂蛋白a[LP(a)]、血管内皮生长因子(VEGF)、脂蛋白相关磷脂酶A2(LP-PLA2)在监测冠心病病情方面的临床意义。方法回顾性分析我院收治的冠心病患者192例,依据冠脉造影检查结果对其进行分组,分为单支、双支、多支冠脉病变组以及轻度、中度以及重度狭窄组;另选健康体检者为对照组;对比不同检查结果下冠心病患者、对照组之间的血清HIF-1α、LP(a)、VEGF、LP-PLA2水平,分析各指标间的差异以及对病情程度的监测意义。结果比较不同冠脉分支组的血清HIF-1α、LP(a)、VEGF、LP-PLA2水平,病变组均高于对对照组,其中多支病变组水平最高,单支病变组最低;不同病情程度的指标水平对比,病变组高于对照组,重度组水平高于中度组,中度组高于轻度组,差异具有统计学意义(P<0.05);ROC曲线分析,血清HIF-1α、LP(a)、VEGF、LP-PLA2评估中重度冠心病的AUC分别为0.865、0.751、0.799、0.782,联合评估AUC为0.887。结论血清HIF-1α、LP(a)、VEGF、LP-PLA2水平变化与冠心病患者病情变化相关,临床可通过检测这4项指标变化评估冠心病患者具体病情。Objective To analyze clinical significances of serum hypoxia inducible factor-1α(HIF-1α),lipoprotein a[LP(a)],vascular endothelial growth factor(VEGF),and lipoprotein associated phospholipase A2(LP-PLA2)in monitoring the condition of coronary heart disease.Methods A retrospective analysis was conducted on 192 patients with coronary heart disease admitted to our hospital.Based on results of coronary angiography,these patients were divided into single vessel,double vessel,and multi-vessel coronary disease groups,as well as mild,moderate,and severe stenosis groups;We also selected healthy examinees as the control group;Comparisons of serum HIF-1 levels between coronary heart disease patients and control groups under different examination resultsαwere conducted.We evaluated differences between LP(a),VEGF,and LP-PLA2 levels,as well as the significance of monitoring the severity of the disease.Results Comparison of serum HIF-1 levels among different coronary branch groupsαshowed that levels of LP(a),VEGF,and LP-PLA2 in the lesion group were higher than those in the control group,with the highest levels in the multi vessel lesion group and the lowest levels in the single vessel lesion group;The comparison of indicator levels for different degrees of illness showed that the medical record group was higher than the control group,the severe group was higher than the moderate group,and the moderate group was higher than the mild group,with significant differences(P<0.05);ROC curve showed that AUCs of moderate to severe coronary heart disease evaluated by serum HIF-1α,LP(a),VEGF,and LP-PLA2 were 0.865,0.751,0.799,and 0.782,respectively,and the combined AUC was 0.887.Conclusion Changes in levels of serum HIF-1α,LP(a),VEGF,and LP-PLA2 are related to changes in the condition of coronary heart disease patients.Clinical evaluation of the specific condition of coronary heart disease patients can be achieved by detecting levels of these four indicators.

关 键 词：冠心病 血清低氧诱导因子-1α 脂蛋白A 血管内皮生长因子 脂蛋白相关磷脂酶A2 冠脉病变支数 病变程度 

分 类 号：R541.4[医药卫生—心血管疾病]