环泊酚用于老年患者经内镜逆行胰胆管造影胆总管取石术中的麻醉效果与安全性评价  

Evaluation of Anesthetic Effect and Safety of Ciprofol in Elderly Patients Undergoing Endoscopic Retrograde Cholangiopancreatography Choledochotomy

作　　者：高瑞[1] 刘玲 Gao Rui;Liu Ling(The Second Affiliated Hospital of Baotou Medical College,Baotou 014030,Inner Mongolia Autonomous Region,China)

机构地区：[1]包头医学院第二附属医院,内蒙古自治区包头014030

出　　处：《中外医药研究》2024年第21期9-12,共4页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

摘　　要：目的:评价环泊酚在老年患者经内镜逆行胰胆管造影(ERCP)胆总管取石术中的麻醉效果与安全性。方法:选取2023年1月—2024年1月于包头医学院第二附属医院行ERCP胆总管取石术的老年患者100例作为研究对象,随机分为环泊酚组与丙泊酚组,各50例,麻醉药分别为环泊酚与丙泊酚。比较两组患者血流动力学及脑电双频指数(BIS)指标、临床相关指标、术中及术后不良反应发生率。结果:入室前(T0),两组心率(HR)、平均动脉压(MAP)、血氧饱和度(SpO2)、BIS比较,差异无统计学意义(P>0.05);诱导后(T1)、进镜前(T2)、置入十二指肠乳头时(T3)、退镜时(T4)、苏醒时(T5),两组HR、MAP、BIS低于T0,差异有统计学意义(P<0.05);环泊酚组T1、5的SpO2低于T0,T2~4的SpO2高于T0,差异有统计学意义(P<0.05);丙泊酚组T1~5的SpO2低于T0,差异有统计学意义(P<0.05)。环泊酚组T1~5的HR、MAP与T2~5的SpO2高于丙泊酚组,差异有统计学意义(P<0.05);T1~5,两组BIS比较,差异无统计学意义(P>0.05)。环泊酚组诱导成功时间长于丙泊酚组,苏醒时间及离室时间短于丙泊酚组,差异有统计学意义(P=0.001)。环泊酚组术中及术后不良反应发生率均低于丙泊酚组,差异有统计学意义(P<0.05)。结论:在老年患者ERCP胆总管取石术中应用环泊酚的麻醉效果较好,可稳定血流动力学及BIS,安全性较高。Objective:To evaluate the anesthetic effect and safety of ciprofol in elderly patients undergoing endoscopic retrograde cholangiopancreatography(ERCP)choledochotomy.Methods:A total of one hundred elderly patients who underwent ERCP choledochotomy in the Second Affiliated Hospital of Baotou Medical College from January 2023 to January 2024 were selected as the study objects and randomly divided into ciprofol group and propofol group,with fifty cases in each group.The anesthetics were ciprofol and propofol.The hemodynamics and bifrequency index(BIS),clinical related indexes and the incidence of intraoperative and postoperative adverse reactions were compared between the two groups.Results:Before entering the house(T0),there was no significant difference in heart rate(HR),mean arterial pressure(MAP),blood oxygen saturation(SpO2)and BIS between the two groups(P>0.05);HR,MAP and BIS were lower than T0 after induction(T1),before endoscopic procedure(T2),when duodenal papilla was implanted(T3),when endoscopic procedure was removed(T4)and when resuscitation(T5),and the differences were statistically significant(P<0.05);in ciprofol group,SpO2 of T1,5 was lower than T0,and SpO2 of T2-4 was higher than T0,the difference was statistically significant(P<0.05);the SpO2 of T1-5 in propofol group was lower than that of T0,and the difference was statistically significant(P<0.05).HR,MAP of T1-5 and SpO2 of T2-5 of ciprofol group were higher than those of propofol group,and the differences were statistically significant(P<0.05);there was no significant difference in BIS between T1-5(P>0.05).The successful induction time of ciprofol group was longer than that of propofol group,and the recovery time and time from the chamber were shorter than that of propofol group,the difference was statistically significant(P=0.001).The incidence of intraoperative and postoperative adverse reactions in ciprofol group was lower than that in propofol group,and the difference was statistically significant(P<0.05).Conclusion:The application of ciprofol

关 键 词：环泊酚 老年患者 经内镜逆行胰胆管造影 胆总管取石术 

分 类 号：R614[医药卫生—麻醉学]