基于肠-肝轴探讨肝脾相关的实质  

Discussion on essence of liver-spleen correlation based on gut-liver axis

作　　者：崔曼丽 马小虎 朱建平 姜云武 赵燕菲 黄培冬 CUI Manli;MA Xiaohu;ZHU Jianping;JIANG Yunwu;ZHAO Yanfei;HUANG Peidong(Yunnan University of Chinese Medicine,Kunming 650500;The Second Affiliated Hospital of Yunnan University of Chinese Medicine;Changchun University of Chinese Medicine;Pu’er Hospital of Chinese Medicine;The Second Affiliated Hospital of Kunming Medical University)

机构地区：[1]云南中医药大学,昆明650500 [2]云南中医药大学第二附属医院 [3]长春中医药大学 [4]普洱市中医医院 [5]昆明医科大学第二附属医院

出　　处：《现代中医临床》2024年第4期52-55,共4页Modern Chinese Clinical Medicine

基　　金：国家中医药管理局第七批全国老中医药专家学术经验继承工作项目(No.国中医药人教函[2022]76号);国家自然科学基金项目(No.82160938);云南省科技厅科技计划项目(No.202101AZ070001-286)。

摘　　要：肝脾相关理论发源于《黄帝内经》《难经》,后经历代医家不断完善,现已成为中医学诊治疾病及治未病的重要学术观点。该理论指出肝脾生理上克而互用,病理上相互影响,治疗上相辅相成。基于肠-肝轴以及肠道菌群最新研究进展,认为肝脾相关的实质是以肠-肝轴为生理基础,以肠道为中间环节,以肠道菌群为微观通道,从而保证肝脾相关生理上以肝主疏泄和脾主运化为核心的生理功能的正常发挥,病理上肝病及脾、脾病及肝相关联,治疗上以调肝理脾为核心治法治疗肝脾相关疾病。从肠-肝轴及肠道菌群角度阐释肝脾相关的实质,以期为中医药现代化发展提供思路。The theory of liver-spleen correlation,originating from the Huangdi Neijing and Nanjing,has been refined by numerous generations of physicians.It has become a significant academic perspective in traditional Chinese medicine(TCM)for diagnosing and treating diseases,as well as for preventive healthcare.This theory posits that the liver and spleen have a physiological mutual restraint and a pathological interrelationship,which are complementary in treatment.Based on recent research advancements in the gut-liver axis and intestinal flora,it is proposed that the essence of liver-spleen correlation lies in the gut-liver axis as the physiological foundation,the intestine as the intermediate link,and intestinal flora as the microchannel.This framework ensures the normal physiological functions of the liver(which governs the free flow of qi)and the spleen(which governs transportation and transformation).Pathologically,liver diseases affect the spleen and vice versa.The core treatment strategy involves regulating both the liver and spleen.This paper elucidates the essence of liver-spleen correlation from the perspectives of the gut-liver axis and intestinal flora,aiming to provide insights for the modern development of TCM.

关 键 词：肝脾相关 脾 肠-肝轴 肠道菌群 中医药现代化 

分 类 号：R241.6[医药卫生—中医诊断学] R2-03[医药卫生—中医临床基础]