依折麦布结合调脂治疗在脑梗死合并肥胖患者中的应用效果  

Application Effect of Ezetimibe Combined with Lipid-regulating Therapy in Patients with Cerebral Infarction Complicated with Obesity

作　　者：欧章金 姚芳 陈昌海 OU Zhangjin;YAO Fang;CHEN Changhai(Bozhou District People's Hospital of Zunyi City,Zunyi 563100,China;不详)

机构地区：[1]遵义市播州区人民医院,贵州遵义563100

出　　处：《中外医学研究》2024年第22期30-33,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探究依折麦布结合调脂治疗在脑梗死合并肥胖患者中的应用效果。方法:选取2021年7月—2023年7月遵义市播州区人民医院收治的108例脑梗死合并肥胖患者,按随机数表法分为两组,各54例。对照组予以调脂治疗,观察组在此基础上予以依折麦布。对比两组相关脂肪因子水平、脂代谢指标[总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、甘油三酯(TG)]、美国国立卫生研究院卒中量表(NIHSS)、改良Rankin量表(mRS)、日常生活活动能力(ADL)。结果:治疗后,观察组脂代谢指标、脂肪因子水平均优于对照组,差异有统计学意义(P<0.05)。治疗后,观察组mRS评分、NIHSS评分均低于对照组,ADL评分高于对照组,差异有统计学意义(P<0.05)。结论:脑梗死合并肥胖患者使用调脂药物联合依折麦布药物治疗,可有效改善患者脂肪代谢异常及脂肪因子水平,修复受损神经,改善肢体功能和协调性,临床疗效显著。Objective:To explore the effect of Ezetimibe combined with lipid-regulating therapy in patients with cerebral infarction and obesity.Method:A total of 108 patients with cerebral infarction complicated with obesity admitted to Bozhou District People's Hospital of Zunyi City from July 2021 to July 2023 were selected and divided into two groups according to random number table method,with 54 patients in each group.The control group was treated with lipid-regulating therapy,and the observation group was treated with Ezetimibe on this basis.The levels of relevant adipokines,lipid metabolism indexes[total cholesterol(TC),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),triglycerides(TG)],National Institutes of Health stroke scale(NIHSS),modified Rankin scale(mRS),and activities of daily living(ADL)were compared between the two groups.Result:After treatment,the lipid metabolism indexes and adipokine levels in the observation group were better than those in the control group,the differences were statistically significant(P<0.05).After treatment,mRS scores and NIHSS scores in the observation group were lower than those in the control group,and ADL scores were higher than those in the control group,the differences were statistically significant(P<0.05).Conclusion:In patients with cerebral infarction complicated with obesity,the use of lipid-regulating drugs combined with Ezetimibe can effectively improve the abnormal fat metabolism and adipokine levels of patients,repair damaged nerves,improve limb function and coordination,and the clinical effect is significant.

关 键 词：依折麦布 调脂治疗 脑梗死合并肥胖 脂代谢 相关脂肪因子水平 

分 类 号：R589.2[医药卫生—内分泌] R743.33[医药卫生—内科学]