利拉鲁肽治疗男性肥胖型糖尿病合并性腺功能减退症患者的临床效果  

Clinical Effect of Liraglutide in Treatment of Male Patients with Obese Diabetic Mellitus and Hypogonadism

作　　者：耿宝川 GENG Baochuan(Changzhou Hospital of Traditional Chinese Medicine,Changzhou 213000,China)

机构地区：[1]常州市中医医院,江苏常州213000

出　　处：《中外医学研究》2024年第22期55-58,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探讨利拉鲁肽治疗男性肥胖型糖尿病合并性腺功能减退症患者的临床效果。方法:选取2020年3月—2023年3月常州市中医医院内分泌科收治的120例男性肥胖型糖尿病合并性腺功能减退症患者作为研究对象,按治疗方式分为两组,各60例。对照组给予常规对症治疗并使用二甲双胍调节血糖,观察组在对照组基础上给予利拉鲁肽联合治疗,两组均观察3个月。比较两组治疗前后糖代谢指标[空腹血糖(FPG)、糖化血红蛋白(HbA1c)、胰岛素抵抗指数(HOMA-IR)、胰岛β细胞功能指数(HOMA-β)]、脂代谢指标[总胆固醇(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)]、肾功能指标[胱抑素C(Cys C)、随机尿白蛋白/肌酐比值(UACR)]、睾酮水平(总睾酮、游离睾酮)及中老年男性雄激素缺乏量表(ADAM)阳性率。结果:治疗前,两组糖代谢指标、脂代谢指标、肾功能指标、睾酮水平比较,差异无统计学意义(P>0.05),治疗后,两组FPG、HbA1c、HOMA-IR、TG、LDL-C、UACR水平均低于治疗前,Cys C、HOMA-β、HDL-C水平高于治疗前,且观察组FPG、HbA1c、HOMA-IR、TG、LDL-C、UACR水平低于对照组,Cys C、HOMA-β、HDL-C水平高于对照组,差异有统计学意义(P<0.05)。治疗后,观察组总睾酮、游离睾酮水平高于治疗前,差异有统计学意义(P<0.05)。观察组ADAM阳性率低于对照组,差异有统计学意义(P<0.05)。结论:男性肥胖型糖尿病合并性腺功能减退症患者使用胰高糖素样肽-1受体激动剂治疗效果较好,可有效控制患者血糖水平,改善胰岛素抵抗、脂代谢水平及肾功能,提升患者睾酮水平,降低ADAM阳性率。Objective:To investigate the clinical effect of Liraglutide in the treatment of male patients with obese diabetes mellitus and hypogonadism.Method:A total of 120 male patients with obese diabetes mellitus and hypogonadism who admitted to the Endocrinology Department of Changzhou Hospital of Traditional Chinese Medicine from March 2020 to March 2023 were selected as the study objects and divided into two groups according to treatment methods,with 60 cases in each group.The control group was given conventional symptomatic treatment and Metformin to regulate blood glucose,and the observation group was given Liraglutide combined treatment on the basis of the control group,and both groups were observed for 3 months.Glucose metabolism indexes[fasting blood glucose(FPG),glycated hemoglobin(HbA1c),insulin resistance index(HOMA-IR),islet beta cell function index(HOMA-β)],lipid metabolism indexes[total cholesterol(TG),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C)],renal function index[cystatin C(Cys C),random urinary albumin/creatinine ratio(UACR)],testosterone level(total testosterone,free testosterone)before and after treatment and androgen deficiency scale(ADAM)positive rate in middle-aged and elderly men were compared between the two groups.Result:Before treatment,there were no statistically significant differences between two groups in glycemic metabolism,lipid metabolism,renal function and testosterone levels(P>0.05).After treatment,the levels of FPG,HbA1c,HOMA-IR,TG,LDL-C and UACR were lower than before treatment,while the levels of Cys C,HOMA-βand HDL-C were higher than before treatment,the levels of FPG,HbA1c,HOMA-IR,TG,LDL-C and UACR in the observation group were lower than those in the control group,while the levels of Cys C,HOMA-βand HDL-C were higher than those in the control group,the differences were statistically significant(P<0.05).After treatment,the levels of total testosterone and free testosterone in the observation group were higher than those before treatme

关 键 词：2型糖尿病 肥胖/超重 性腺功能减退 利拉鲁肽 

分 类 号：R587.2[医药卫生—内分泌] R697.22[医药卫生—内科学]