产后逐瘀胶囊联合卡前列素氨丁三醇治疗产后出血的临床研究  

Clinical study on Chanhou Zhuyu Capsules combined with carboprost tromethamine in treatment of postpartum hemorrhage

作　　者：张喜亚 王博 田立慧 ZHANG Xiya;WANG Bo;TIAN Lihui(Department of Obstetrics and Gynecology,Tianjin Peking University Medical Offshore Oil Hospital,Tianjin 300452,China)

机构地区：[1]天津北大医疗海洋石油医院妇产科,天津300452

出　　处：《现代药物与临床》2024年第7期1834-1837,共4页Drugs & Clinic

摘　　要：目的 探讨产后逐瘀胶囊联合卡前列素氨丁三醇注射液治疗产后出血的临床疗效。方法 选取天津北大医疗海洋石油医院在2022年1月—2023年12月收治的86例产后出血患者,按治疗方案不同将患者分为对照组和治疗组,每组43例。对照组肌肉注射卡前列素氨丁三醇注射液,1支/次,1次/d。治疗组患者在对照组基础上口服产后逐瘀胶囊,3粒/次,3次/d。两组持续治疗2 d。比较两组的临床疗效、分娩后出血量、子宫复旧情况、血清指标。结果 治疗组患者的治愈率为93.02%,对照组的治愈率为76.74%,组间差异显著(P<0.05)。治疗后,治疗组分娩后2 h和2~24 h的出血量明显少于对照组(P<0.05)。治疗后,两组的子宫残留物面积、子宫三径均小于治疗前(P<0.05);治疗组的子宫残留物面积、子宫三径小于对照组(P<0.05)。治疗后,两组的抗凝血酶Ⅲ(AT-Ⅲ)显著升高,纤维蛋白原(FIB)、D-二聚体(D-D)显著降低(P<0.05);治疗组的AT-Ⅲ高于对照组,FIB、D-D低于对照组(P<0.05)。结论 产后逐瘀胶囊联合卡前列素氨丁三醇注射液可提高产后出血的临床疗效,降低出血量,促进子宫复旧,调节凝血和纤溶功能。Objective To investigate the clinical effect of Chanhou Zhuyu Capsules combined with Carboprost Tromethamine Injection in treatment of postpartum hemorrhage. Methods Patients (86 cases) with postpartum hemorrhage in Tianjin Peking University Medical Offshore Oil Hospital from January 2022 to December 2023 were randomly divided into control and treatment groups according to different treatment plans, and each group had 43 cases. Patients in the control group were im administered with Carboprost Tromethamine Injection, 1 piece/time, once daily. Patients in the treatment group were po administered with Chanhou Zhuyu Capsules on the basis of the control group, 3 grains/time, three times daily. Patients in two groups were treated for 2 d. The clinical efficacies, postpartum bleeding volume, uterine involution, and serum indicators in two groups were compared. Results The cure rate in the treatment group (93.02%) was significantly higher than 76.74% in the control group, and the difference was significant between groups (P < 0.05). The amounts of blood loss 2 h and 2—24 h after delivery in the treatment group was lower than those in the control group (P < 0.05). After treatment, the area of uterine residue and three diameters of uterus in two groups were lower than those before treatment (P < 0.05), and the area of uterine residue and the uterine diameter of the treatment group were lower than those of the control group (P < 0.05). After treatment, the levels of AT-III in two groups were significantly increased, while the levels of FIB and D-D in two groups were significantly decreased (P < 0.05). The levels of AT-III in the treatment group were higher than those in the control group, while the levels of FIB and D-D in the treatment group were lower than those in the control group (P < 0.05). Conclusion Chanhou Zhuyu Capsules combined with Carboprost Tromethamine Injection has clinical effect in treatment of postpartum hemorrhage, can reduce bleeding volume, promote uterine involution, regulate coagulation and fibrin

关 键 词：产后逐瘀胶囊 卡前列素氨丁三醇注射液 产后出血 出血量 子宫残留物面积 子宫三径 抗凝血酶Ⅲ 纤维蛋白原 D-二聚体 

分 类 号：R984[医药卫生—药品]