白花蛇舌草抗肿瘤作用机制的研究进展  

Research progress on antitumor effects of Hedyotidis Diffusae Herba

作　　者：李慧 李军[1] 徐瑞 LI Hui;LI Jun;XU Rui(School of Basic Medicine,Shaanxi University of Chinese Medicine,Xianyang 712046,China;Shaanxi Cancer Tumor Hospital,Xi’an 710000,China)

机构地区：[1]陕西中医药大学基础医学院,陕西咸阳712046 [2]陕西省肿瘤医院,陕西西安710000

出　　处：《现代药物与临床》2024年第7期1921-1926,共6页Drugs & Clinic

基　　金：陕西省自然科学基础研究计划项目(2023-JC-YB-711)。

摘　　要：癌症是现在临床上导致死亡的主要原因。白花蛇舌草为茜草科耳草属植物,在恶性肿瘤治疗中应用广泛。白花蛇舌草可抑制肿瘤细胞增殖,诱导肿瘤细胞程序性死亡,抑制肿瘤细胞侵袭和迁移,抑制肿瘤血管生成,增加化疗药物敏感性,调节机体免疫。综述了白花蛇舌草抗肿瘤的作用机制研究进展,以期为白花蛇舌草抗肿瘤的临床应用提供依据。Cancer is currently the main cause of death in medical clinical practice. Hedyotis diffusa Willd. is a plant species belonging to the Hedyotis Linn. Rubiaceae family and is widely used in treatment of malignant tumors. Hedyotidis Diffusae Herba can inhibit the proliferation of tumor cells, induce programmed cell death, inhibit the invasion and migration of tumor cells, inhibit tumor angiogenesis, increase chemotherapy drug sensitivity, and regulate the body's immune system. This article reviews the research progress on anti-tumor mechanism of Hedyotidis Diffusae Herba, in order to provide a basis for its clinical application in anti-tumor therapy.

关 键 词：白花蛇舌草 抗肿瘤 细胞增殖 细胞程序性死亡 细胞侵袭 肿瘤血管生成 化疗药物敏感性 机体免疫 

分 类 号：R285.5[医药卫生—中药学]