青藤碱防治肝癌的药理作用研究进展  

Research progress on pharmacological effects of sinomenine in prevention and treatment of liver cancer

作　　者：陈杉 吴芬 徐大兴 曾斌芳[3] CHEN Shan;WU Fen;XU Daxing;ZENG Binfang(Department of Traditional Chinese Medicine,Tongling Traditional Chinese Medicine Hospital,Tongling 244000,China;Department of Oncology,Tongling Traditional Chinese Medicine Hospital,Tongling 244000,China;School of Traditional Chinese Medicine,Xinjiang Medical University,Urumqi 830017,China)

机构地区：[1]铜陵市中医医院中医内科,安徽铜陵244000 [2]铜陵市中医医院肿瘤科,安徽铜陵244000 [3]新疆医科大学中医学院,新疆乌鲁木齐830017

出　　处：《现代药物与临床》2024年第7期1932-1936,共5页Drugs & Clinic

基　　金：新疆维吾尔自治区区域协同创新专项(上海合作组织科技伙伴计划及国际科技合作计划)项目(2022E01008)。

摘　　要：肝癌是癌症死亡最常见原因之一,大多数类型的肝癌对化疗具有高度耐药性。青藤碱是从青藤的根和茎中提取的吗啡烷型生物碱,具有多种药理作用,通过促进肿瘤细胞凋亡、抑制肿瘤细胞增殖、阻止肿瘤细胞侵袭和转移、调节免疫功能、与抗癌药物发挥协同作用防治肝癌。总结了青藤碱防治肝癌的药理作用研究进展,希望为青藤碱临床治疗肝癌提供参考。Liver cancer is one of the most common causes of cancer death, and most types of liver cancer have high resistance to chemotherapy. Sinomenine is a morphine alkaloid extracted from the roots and stems of Cocculus trilopus. (Thunb.) DC. and it has various pharmacological effects. Sinomenine can promote tumor cell apoptosis, inhibit tumor cell proliferation, prevent tumor cell invasion and metastasis, regulate immune function, and has synergistic effects with anti-cancer drugs to prevent and treat liver cancer. This article summarizes the pharmacological research progress of sinomenine in prevention and treatment of liver cancer, hoping to provide reference for the clinical treatment of liver cancer with sinomenine.

关 键 词：青藤碱 肝癌 细胞凋亡 细胞增殖 细胞侵袭 免疫功能 协同作用 

分 类 号：R965[医药卫生—药理学]