湿润烧伤膏联合他克莫司软膏治疗激素依赖性皮炎对患者血清炎性因子、皮肤屏障功能的影响  

Impact of Moist Exposed Burn Ointment Combined with Tacrolimus Ointment on Se Barrier Function of Patients with Hormone-Dependent Dermatitis

作　　者：张方 闫静 赵俊芳 ZHANG Fang;YAN Jing;ZHAO Junfang(Burn Plastic Surgery Clinic,Nanyang Nanshi Hospital,Nanyang 473000,China)

机构地区：[1]南阳南石医院烧伤整形美容门诊,河南南阳473000

出　　处：《临床医学工程》2024年第8期929-930,共2页Clinical Medicine & Engineering

基　　金：南阳市科技攻关计划项目(KJGG113)。

摘　　要：目的 分析湿润烧伤膏联合他克莫司软膏治疗激素依赖性皮炎的效果。方法 90例激素依赖性皮炎患者随机分为两组,对照组给予他克莫司软膏治疗,联合组在对照组基础上给予湿润烧伤膏治疗,比较两组的炎性因子、皮肤屏障功能及疗效。结果 治疗后,联合组的血清IFN-γ、 IL-4水平均显著低于对照组,角质层含水量、油脂含量、总有效率均显著高于对照组(P<0.05)。结论 湿润烧伤膏联合他克莫司软膏治疗激素依赖性皮炎的效果显著,可抑制患者的炎性反应,修复其皮肤屏障功能。Objective To analyze the effect of moist exposed burn ointment combined with tacrolimus ointment in the treatment of hormone-dependent dermatitis.Methods 90 patients with hormone-dependent dermatitis were randomly divided into two groups.The control group was treated with tacrolimus ointment,and the combined group was treated with moist exposed burn ointment on the basis of the control group.The inflammatory factors,skin barrier function and efficacy were compared between the two groups.Results After treatment,the levels of serum IFN-y and IL-4 in the combined group were significantly lower than those in the control group,and the cuticle water content,oil content and total effective rate were significantly higher than those in the control group(P<0.05).Conclusions Moist exposed burn ointment combined with tacrolimus ointment in the treatment of hormone-dependent dermatitis has significant effect,which can inhibit the inflammatory response of patients and repair their skin barrier function.[Keywords]Moist exposed burn ointment;Tacrolimus ointment;Hormone-dependent dermatitis;Inflammatory factor.

关 键 词：湿润烧伤膏 他克莫司软膏 激素依赖性皮炎 炎性因子 

分 类 号：R275.9[医药卫生—中西医结合]