尼卡地平联合甲基多巴治疗妊娠期高血压疾病的效果  

Effect of Nicardipine Combined with Methyldopa in the Treatment of Hypertensive Disorder Complicating Pregnancy

作　　者：黄立用 仵晓峰 苏瑞金 HUANG Liyong;WU Xiaofeng;SU Ruijin(Department of Obstetrics,Nanyang Wolong Matemal and Child Health Care Hospital,Nanyang 473000,Henan,China;Department of Gynaecology and Obstetrics,Nanyang Wolong Matemal and Child Health Care Hospital,Nanyang 473000,Henan,China)

机构地区：[1]南阳市卧龙区妇幼保健院产科,河南南阳473000 [2]南阳市卧龙区妇幼保健院妇产科,河南南阳473000

出　　处：《中国药物滥用防治杂志》2024年第7期1253-1256,共4页Chinese Journal of Drug Abuse Prevention and Treatment

基　　金：南阳市卧龙区妇幼保健院项目(编号:2023-01)。

摘　　要：目的:研究尼卡地平联合甲基多巴对妊娠期高血压疾病患者的疗效。方法:选择2020年1月—2022年12月我院收治的122例妊娠期高血压疾病患者,随机分为对照组和观察组,每组61例。对照组单用尼卡地平,观察组联用甲基多巴。比较两组妊娠结局、临床症状、血压指标、血清胃饥饿素(ghrelin)、血管内皮细胞生长因子(VEGF)、内皮素-1(ET-1)和同型半胱氨酸(Hcy)水平。结果:观察组产后出血、胎儿宫内窘迫、剖宫产、新生儿窒息和早产发生率低于对照组(P<0.05);观察组舒张压、阻力指数、S/D比值和收缩压低于对照组(P<0.05);观察组的蛋白尿、恶心、血压升高、头晕和水肿症状评分明显低于对照组(P<0.05);观察组血清ghrelin水平高于对照组,VEGF、ET-1和Hcy水平低于对照组(P<0.05)。结论:针对妊娠期高血压疾病患者,尼卡地平联合甲基多巴可改善妊娠结局、临床症状,降低血压及VEGF、ET-1和Hcy水平,并提高血清ghrelin,进而有利于患者的机体恢复。Objective:To study the eficacy of nicardipine combined with methyldopa in patients with hypertensive disorder complicating pregnancy.Methods:A total of 122 patients with hypertensive disorder complicating pregnancy admitted to our hospital from January 2020 to December 2022 were randomly divided into control group and observation group,with 61 patients in each group.The control group was treated with nicardipine alone,and the observation group was treated with methyldopa.The pregnancy outcomes,clinical symptoms,blood pressure indexes,serum ghrelin,vascular endothelial growth factor(VEGF),endothelin-1(ET-1)and homocysteine(Hcy)levels were compared between the two groups.Results:The incidences of postpartum hemorrhage,fetal distress,cesarean section,neonatal asphyxia and premature delivery in the observation group were lower than those in the control group(P<0.05).The diastolic blood pressure,resistance index,S/D ratio and systolic blood pressure in the observation group were lower than those in the control group(P<0.05).The scores of proteinuria,nausea,elevated blood pressure,dizziness and edema in the observation group were significantly lower than those in the control group(P<0.05).The serum ghrelin level in the observation group was higher than that in the control group,and the levels of VEGF,ET-1 and Hcy were lower than those in the control group(P<0.05).Conclusion:For patients with hypertensive disorder complicating pregnancy,nicardipine combined with methyldopa can improve pregnancy outcomes and clinical symptoms,reduce blood pressure and VEGF,ET-1 and Hcy levels,and increase serum ghrelin,which is conducive to the recovery of the patient's body.

关 键 词：尼卡地平 甲基多巴 妊娠期高血压疾病 

分 类 号：R714.246[医药卫生—妇产科学]