新活素联合多巴酚丁胺治疗急性心肌梗死合并心源性休克患者的效果  

Effect of rhBNP Combined with Dobutamine in the Treatment of Patients with Acute Myocardial Infarction Complicated with Cardiogenic Shock

作　　者：王鑫 林静[1] 龚洪申[1] 马婉嫕[1] WANG Xin;LIN Jing;GONG Hongshen;MA Wanyi(Emergency Department of Zhengzhou Third People's Hospital,Zhengzhou 450000,Henan,China)

机构地区：[1]郑州市第三人民医院急诊科,河南郑州450000

出　　处：《中国药物滥用防治杂志》2024年第7期1268-1271,共4页Chinese Journal of Drug Abuse Prevention and Treatment

摘　　要：目的:探究新活素联合多巴酚丁胺治疗急性心梗合并心源性休克患者的效果。方法:回顾分析我院2019年5月—2021年5月收治的96例急性心梗合并心源性休克患者病历资料,按照使用药物种类分为对照组(n=48)与研究组(n=48),其中对照组单独使用多巴酚丁胺治疗,研究组在对照组基础上增用新活素进行辅助治疗,比较两组心肌损伤标志物(cTn-I,肌钙蛋白、BNP,脑钠肽)以及心功能指标(LVEF,左室射血分数、LVEDD,左心室舒张末期内径、CI,心脏指数、SV,心搏量),同时记录两组患者治疗期间的不良反应(恶心呕吐、皮肤瘙痒、嗜睡)发生情况,随访半年内患者心血管不良事件(心律失常、心力衰竭、再发心梗、心源性猝死)发生情况。结果:研究组干预后cTn-I、BNP水平低于对照组,LVEF、LVEDD、CI、SV高于对照组(P<0.05)。对照组与研究组不良反应发生率比较,差异无统计学意义(P>0.05)。研究组治疗临床总有效率为95.83%,高于对照组的83.33%(P<0.05)。研究组心血管不良事件发生率为4.17%,低于对照组的16.67%(P<0.05)。结论:新活素与多巴酚丁胺联合治疗急性心肌梗死合并心源性休克的临床疗效良好,可有效改善患者的心功能,降低心血管不良事件发生率,且并不增加药物不良反应,具有较高的用药安全性。Objective:To explore the effect of rhBNP combined with dobutamine in the treatment of patients with acute myocardial infarction complicated with cardiogenic shock.Methods:The medical records of 96 patients with acute myocardial infarction complicated with cardiogenic shock admitted to our hospital from May 2019 to May 2021 were retrospectively analyzed.According to the types of drugs used,they were divided into control group(n=48)and study group(n=48).The control group was treated with dobutamine alone,and the study group was treated with rhBNP on the basis of the control group.Myocardial injury markers(cTn-I,troponin,BNP,brain natriuretic peptide)and cardiac function indicators(LVEF,left ventricular ejection fraction,LVEDD,left ventricular end-diastolic diameter,CI,cardiac index,SV,cardiac volume)were compared between the two groups.At the same time,the incidence of adverse reactions(nausea and vomiting,skin itching,drowsiness)during the treatment of the two groups of patients was recorded,and the incidence of cardiovascular adverse events(arrhythmia,heart failure,recurrent myocardial infarction,sudden cardiac death)was followed up for half a year.Results:After intervention,the levels of cardiac cTn-I and BNP in the study group were lower than those in the control group,and LVEF,LVEDD,CI and SV were higher than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the control group and the study group(P>0.05).The total effective rate of treatment in the study group was 95.83%,which was higher than 83.33%in the control group(P<0.05).The incidence of cardiovascular adverse events in the study group was 4.17%,which was lower than 16.67%in the control group(P<0.05).Conclusion:The combination of rhBNP and dobutamine has a good clinical effect in the treatment of acute myocardial infarction complicated with cardiogenic shock,which can effectively improve the cardiac function of patients,reduce the incidence of cardiovascular adverse events,and does not inc

关 键 词：新活素 多巴酚丁胺 急性心梗 心源性休克 

分 类 号：R542.22[医药卫生—心血管疾病] R541.64[医药卫生—内科学]