帕拉米韦氯化钠注射液联合热毒宁注射液治疗儿童流感病毒肺炎的效果  

Effect of Peramivir Sodium Chloride Injection Combined with Reduning Injection in the Treatment of Influenza Virus Complicated with Pneumonia in Children

作　　者：刘亚娜 孟永胜 石欢欢 赵文生 石宏 LIU Yana;MENG Yongsheng;SHI Huanhuan;ZHAO Wensheng;SHI Hong(Kaifeng Central Hospital,Kaifeng 475000,Henan,China)

机构地区：[1]开封市中心医院,河南开封475000

出　　处：《中国药物滥用防治杂志》2024年第7期1303-1307,共5页Chinese Journal of Drug Abuse Prevention and Treatment

基　　金：河南省中医药管理局科研项目(编号:2022HN127)。

摘　　要：目的:观察帕拉米韦氯化钠注射液联合热毒宁注射液治疗儿童流感病毒肺炎的临床效果。方法:选择2020年11月—2021年2月在我院诊治的100例流感病毒肺炎患儿为研究对象,根据不同治疗方案分为对照组(n=50)和试验组(n=50),对照组给予帕拉米韦氯化钠注射液治疗,试验组在给予帕拉米韦氯化钠注射液治疗基础上联合热毒宁注射液治疗,比较两组临床效果、不良反应、临床症状缓解时间、住院时长及炎症指标。结果:试验组体温缓解时间、咳嗽缓解时间、住院时长短于对照组(P<0.05);试验组IL-6水平低于对照组(P<0.05),而两组治疗前后PCT水平比较,差异无统计学意义(P>0.05);试验组治疗总有效率高于对照组(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:帕拉米韦氯化钠注射液联合热毒宁注射液可提升儿童流感病毒肺炎治疗效果,有效缓解患儿临床症状,抑制炎症因子水平,缩短住院时间,且并增加不良反应发生几率。Objective:To observe the clinical effect of peramivir sodium chloride injection combined with Reduning injection in the treatment of influenza virus pneumonia in children.Methods:A total of 100 children with influenza virus complicated with pneumonia diagnosed and treated in our hospital from November 2020 to February 2021 were selected as the research objects.According to different treatment schemes,they were divided into control group(n=50)and experimental group(n=50).The control group was treated with peramivir sodium chloride injection,and the experimental group was treated with peramivir sodium chloride injection combined with reduning injection.The clinical effects,adverse reactions,clinical symptom relief time,hospitalization time and inflammation indexes were compared between the two groups.Results:he body temperature relief time,cough relief time and hospitalization time in the experimental group were shorter than those in the control group(P<0.05).The level of IL-6 in the experimental group was lower than that in the control group(P<0.05),but there was no significant difference in PCT level between the two groups before and after treatment(P>0.05).The total effective rate of treatment in the experimental group was higher than that in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Paramivir sodium chloride injection combined with Reduning injection can improve the therapeutic effect of influenza virus complicated with pneumonia in children,effectively alleviate the clinical symptoms of children,inhibit the level of inflammatory factors,shorten the hospitalization time,and increase the incidence of adverse reactions.

关 键 词：帕拉米韦氯化钠注射液 热毒宁注射液 儿童 流感病毒肺炎 

分 类 号：R725.6[医药卫生—儿科]