从胆汁酸代谢阐释肝脾失调在痰湿体质易发代谢紊乱中的作用机制  

Mechanism of Liver-spleen Disharmony in Inducing Metabolic Diseases in Phlegm-dampness Constitution from the Perspective of Bile Acid Metabolism

作　　者：吴玉琦 张安琪 万瑾毅 姚海强[1] WU Yuqi;ZHANG Anqi;WAN Jinyi;YAO Haiqiang(Beijing University of Chinese Medicine,Beijing 100029,China)

机构地区：[1]北京中医药大学,北京100029

出　　处：《世界中医药》2024年第15期2303-2307,共5页World Chinese Medicine

基　　金：国家自然科学基金项目(82274379);中华中医药学会“青年人才托举工程”项目(CACM-2019-QNRC2-A01);中央高校基本科研业务费专项(2020-JYB-XJSJJ-003)。

摘　　要：肝脾失调是常见的中医临床证候之一,表现为脾主运化和肝主疏泄失调,影响机体水液代谢,造成痰湿内蕴等代谢异常,是痰湿“体-病”转变的重要病机之一。胆汁酸参与机体的肝肠循环,对人体的糖脂代谢具有广泛的调控作用。通过从微观层面探讨胆汁酸作为中医“肝脾失调”理论的物质基础,揭示胆汁酸代谢与肝脾失调的科学内涵,力图从新的角度为痰湿体质易发代谢紊乱的病机提供科学阐释。此外,通过中药调节胆汁酸谱作为干预方式,可有效改善痰湿体质诱发的代谢紊乱,拓展中医痰湿体质研究的广度和深度,为痰湿临床调体提供新的研究思路和干预靶点。Liver-spleen disharmony is a common clinical syndrome in traditional Chinese medicine(TCM),characterized by the dysfunction of the spleen in transportation and transformation and the liver in free flow of qi,which affects the body′s water metabolism and leads to metabolic abnormalities such as the accumulation of phlegm and dampness.It is a key pathogenesis in the transition from a phlegm-dampness constitution to disease.Bile acids play a role in the enterohepatic circulation and have extensive regulatory effects on glucose and lipid metabolism in the body.By the investigation of bile acids as the material basis for the TCM theory of liver-spleen disharmony at a microscopic level,the scientific connotation of bile acid metabolism and liver-spleen disharmony can be revealed.This approach aims to provide a scientific explanation for the pathogenesis of metabolic disorders in individuals with a phlegm-dampness constitution from a new perspective.Moreover,regulating the bile acid profile through Chinese medicine can effectively improve the metabolic disorders induced by a phlegm-dampness constitution.This study expands the breadth and depth of TCM research on phlegm-dampness constitutions and provides new research directions and intervention targets for clinical regulation of phlegm-dampness.

关 键 词：胆汁酸 肝脾失调 痰湿体质 糖脂代谢 肝肠循环 代谢紊乱 

分 类 号：R256.4[医药卫生—中医内科学]