补脾益肾类中药复方干预重症肌无力的免疫调节机制研究进展  

Immunomodulatory Mechanism of Spleen-tonifying and Kidneys-benefiting Drugs in the Management of Myasthenia Gravis:A Review

作　　者：吴新新 张悦 黎晓蕾 李皓月 杨俊红[3] 赵静[1] WU Xinxin;ZHANG Yue;LI Xiaolei;LI Haoyue;YANG Junhong;ZHAO Jing(Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China;International Cooperation Department,China Academy of Chinese Medical Sciences,Beijing 100700,China;The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,China)

机构地区：[1]中国中医科学院中医临床基础医学研究所,北京100700 [2]中国中医科学院国际合作处,北京100700 [3]河南中医药大学第一附属医院,郑州450000

出　　处：《世界中医药》2024年第15期2357-2362,2370,共7页World Chinese Medicine

基　　金：国家自然科学基金项目(81974564);河南省中医药科学研究专项(232102311196);中国中医科学院科技创新工程中医临床基础学科创新团队项目(CI2021B003);中国中医科学科技创新工程项目(CI2021A00704-4)。

摘　　要：重症肌无力是一种自身免疫性神经系统难治性疾病,补脾益肾中药复方可通过免疫调节作用发挥确切疗效。故通过归纳治疗重症肌无力相关的补脾益肾类中药复方,并从临床试验和基础实验两方面总结研究方案,分析补脾益肾类中药复方治疗重症肌无力的免疫调节机制,包括降低乙酰胆碱受体抗体和免疫球蛋白G浓度等体液免疫机制,维持Th1/Th2、Th17/Treg动态平衡等细胞免疫机制,为后续补脾益肾类中药复方在重症肌无力治疗中的应用及其免疫机制的研究提供参考。Myasthenia gravis(MG)is a challenging autoimmune nervous system disease.Traditional Chinese medicine(TCM)compounds potent in tonifying the spleen and benefiting kidneys can exert significant effects through immune modulation.This study summarized TCM compounds for tonifying the spleen and benefiting kidneys used in MG treatment,and outlined research strategies from both clinical and basic experimental perspectives to analyze the immunomodulatory mechanisms of these TCM compounds in treating MG,including the reduction of acetylcholine receptor antibodies and immunoglobulin G concentrations(humoral immunity mechanisms),and the maintenance of Th1/Th2 and Th17/Treg balance(cellular immunity mechanisms).This study is expected to provide a reference for the application and immune mechanism research on spleen-tonifying and kidneys-benefiting TCM compounds in the treatment of MG.

关 键 词：重症肌无力 补脾益肾 中药复方 体液免疫 细胞免疫 研究进展 免疫机制 临床应用 

分 类 号：R277.7[医药卫生—中医学]