基于PI3K/AKT信号通路探讨中药治疗激素性股骨头坏死的研究进展  

Chinese Medicine in the Treatment of Steroid-induced Femoral Head Necrosis Based on PI3K/AKT Signaling Pathway:A Review

作　　者：封潇添 马剑雄[1,2,3] 王岩 申佳慧[1,2,3,4] 周丽芸 李奕扬 孙亚迪 董本超 李岩 杨培川 李光[1,2,3] 马天成 崔洪伟 王祺钰[1,2,3,4] 马信龙 FENG Xiaotian;MA Jianxiong;WANG Yan;SHEN Jiahui;ZHOU Liyun;LI Yiyang;SUN Yadi;DONG Benchao;LI Yan;YANG Peichuan;Li Guang;MA Tiancheng;CUI Hongwei;WANG Qiyu;MA Xinlong(Tianjin University Tianjin Hospital of Tianjin University,Tianjin 300211,China;Tianjin Institute of Orthopedics,Tianjin 300050,China;Tianjin Key Laboratory of Orthopedic Biomechanics and Medical Engineering,Tianjin 300050,China;College of Integrative Chinese and Western Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)

机构地区：[1]天津大学天津医院,天津300211 [2]天津市骨科研究所,天津300050 [3]天津市骨科生物力学与医学工程重点实验室,天津300050 [4]天津中医药大学中西医结合学院,天津301617

出　　处：《世界中医药》2024年第15期2363-2370,共8页World Chinese Medicine

基　　金：国家重点研发计划项目(2022YFC3601904);天津市自然科学基金重点项目(22JCZDJC00340)。

摘　　要：激素性股骨头坏死是非创伤性股骨头坏死中最常见的类型,在非创伤性股骨头坏死中占比高达1/3。但现有疗法无法有效延缓该疾病的进展,髋关节置换术往往是晚期股骨头坏死患者的唯一选择。因此寻找一种防治激素性股骨头坏死的新型保髋疗法,减轻患者的痛苦和经济负担是目前亟须解决的难题。近年来研究发现磷脂酰肌醇3-激酶/蛋白激酶B(PI3K/AKT)信号通路与激素性股骨头坏死的发病联系紧密,靶向PI3K/AKT信号通路用药对激素性股骨头坏死疗效显著。中草药是我国中医学的结晶,使用中药治疗疾病具有多靶点、低成本、低不良反应的特点。随着中药药理学研究的不断深入,众多具有补肾强骨、活血化瘀等功效的中药单体和复方被证实能够通过调控PI3K/AKT信号通路治疗激素性股骨头坏死。Hormone-induced femoral head necrosis is the most common type of non-traumatic femoral head necrosis,accounting for up to 1/3 of such cases.Current treatments are inadequate in effectively delaying the progression of this disease,and hip replacement surgery often becomes the only option for advanced cases.Therefore,developing a new hip-preserving treatment to alleviate the suffering and economic burden on patients is an urgent challenge.Recent research has shown a close connection between the phosphatidylinositol 3-kinase/protein kinase B(PI3K/AKT)signaling pathway and hormone-induced femoral head necrosis.Medications targeting the PI3K/AKT signaling pathway have demonstrated significant efficacy in treating this condition.Chinese herbal medicine,a hallmark of traditional Chinese medicine(TCM)science,offers multi-target,low-cost,and low-side-effect therapies.With the ongoing advancement in TCM pharmacology,many Chinese herbal monomers and formulas with functions such as tonifying the kidneys,strengthening bones,activating blood circulation,and resolving blood stasis have been proven effective in treating hormone-induced femoral head necrosis through the regulation of the PI3K/AKT signaling pathway.

关 键 词：激素性股骨头坏死 中药单体 中药复方 药理研究进展 PI3K/AKT信号通路 内皮细胞 成骨细胞 破骨细胞 

分 类 号：R285.6[医药卫生—中药学]