观察利福平、胰岛素联合治疗肺结核合并糖尿病的疗效及安全性  

Observation on the Efficacy and Safety of Rifampicin Combined with Insulin in the Treatment of Pulmonary Tuberculosis Complicated with Diabetes Mellitus

作　　者：淦作梅 廖萌 GAN Zuo-mei;Liao Meng(Department of Infectious Diseases,Wuning County People's Hospital,Wuning 332300,Jiangxi,China)

机构地区：[1]武宁县人民医院感染科,江西武宁332300

出　　处：《医学信息》2024年第16期84-87,共4页Journal of Medical Information

摘　　要：目的观察利福平、胰岛素联合治疗肺结核合并糖尿病的疗效及安全性。方法选取2020年1月-2023年6月我院接诊的62例肺结核合并糖尿病患者为研究对象,采用随机数字表法分为对照组和观察组,各组31例。对照组予以口服降糖药(二甲双胍、阿卡波糖、达格列净)联合利福平治疗,观察组采用胰岛素注射联合利福平治疗。比较两组临床疗效、血糖指标[空腹血糖(FBG)、糖化血红蛋白(HbA1c)、餐后2 h血糖(2hPBG)]、临床症状(发热、咳嗽、咯血)缓解时间、血糖达标时间及不良反应发生率。结果观察组治疗总有效率(93.55%)高于对照组(83.87%)(P<0.05);两组FBG、HbA1c、2 hPBG均低于治疗前,且观察组低于对照组(P<0.05);观察组发热、咳嗽、咯血缓解时间以及血糖达标时间均低于对照组(P<0.05);观察组不良反应发生率(6.45%)低于对照组(19.35%)(P<0.05)。结论利福平联合胰岛素治疗肺结核合并糖尿病可提高治疗效果,有效改善血糖指标,缩短血糖达标和临床症状缓解时间,且不良反应发生率低,是一种可行、有效的治疗方案。Objective To observe the efficacy and safety of rifampicin combined with insulin in the treatment of pulmonary tuberculosis complicated with diabetes mellitus.Methods A total of 62 patients with pulmonary tuberculosis complicated with diabetes mellitus who were admitted to our hospital from January 2020 to June 2023 were selected as the research objects.They were divided into control group and observation group by random number table method,with 31 patients in each group.The control group was treated with oral hypoglycemic drugs(metformin,acarbose,dapagliflozin)combined with rifampicin,and the observation group was treated with insulin injection combined with rifampicin.The clinical efficacy,blood glucose indexes[fasting blood glucose(FBG),glycosylated hemoglobin(HbA1c),2 h postprandial blood glucose(2 hPBG)],remission time of clinical symptoms(fever,cough,hemoptysis),time of blood glucose reaching the standard and incidence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group(93.55%)was higher than that in the control group(83.87%)(P<0.05).The levels of FBG,HbA1 c and 2 hPBG in the two groups were lower than those before treatment,and those in the observation group were lower than those in the control group(P<0.05).The remission time of fever,cough,hemoptysis and the time of blood glucose reaching the standard in the observation group were lower than those in the control group(P<0.05).The incidence of adverse reactions in the observation group(6.45%)was lower than that in the control group(19.35%)(P<0.05).Conclusion Rifampicin combined with insulin in the treatment of pulmonary tuberculosis complicated with diabetes mellitus can improve the therapeutic effect,effectively improve the blood glucose index,shorten the time of blood glucose control and clinical symptom relief,and the incidence of adverse reactions is low.It is a feasible and effective treatment plan.

关 键 词：利福平 胰岛素 肺结核 糖尿病 安全性 

分 类 号：R587.1[医药卫生—内分泌] R521[医药卫生—内科学]