血清胆红素与尿酸检测对冠心病患者临床检验的价值研究  

Study on the Value of Serum Bilirubin and Uric Acid Detection in Clinical Examination of Patients with Coronary Heart Disease

作　　者：李泉 曾丽红 曾艳蕊 LI Quan;ZENG Li-hong;ZENG Yan-rui(Laboratory Department of Ningdu County Hospital of Traditional Chinese Medicine,Ningdu 342800,Jiangxi,China)

机构地区：[1]宁都县中医院检验科,江西宁都342800

出　　处：《医学信息》2024年第16期145-148,共4页Journal of Medical Information

摘　　要：目的研究血清胆红素(BIL)与尿酸(UA)检测对冠心病(CHD)患者的临床检验价值。方法以2021年1月-2023年3月宁都县中医院确诊的60例CHD患者为研究对象,设为CHD组;另取同期体检健康者60例,设为健康组。两组均开展血清BIL、UA检测,比较CHD组与健康组的血清BIL[总胆红素(TBIL)、直接胆红素(DBIL)、间接胆红素(IBIL)]、UA检测结果,分析不同冠脉狭窄分级及不同类型CHD患者的血清BIL、UA水平。以冠脉造影结果为金标准,分析血清BIL、UA单独及联合检测对CHD的诊断效能。结果CHD组血清TBIL、DBIL、IBIL水平低于健康组,UA水平高于健康组(P<0.05);TBIL、DBIL、IBIL水平由高至低依次为Ⅰ级>Ⅱ级>Ⅲ级>Ⅳ级,UA水平由高至低依次为Ⅳ级>Ⅲ级>Ⅱ级>Ⅰ级(P<0.05);TBIL、DBIL、IBIL水平由高至低依次为稳定型心绞痛(SAP)>不稳定型心绞痛(UAP)>急性心肌梗死(AMI),UA水平由高至低依次为AMI>UAP>SAP(P<0.05);血清BIL、UA联合检测对CHD的诊断敏感度、准确度、特异度高于其单独检测(P<0.05)。结论血清BIL、UA检测对CHD疾病具有良好的筛查与鉴别作用,二者联合检测具有更高诊断效能。Objective To study the clinical test value of serum bilirubin(BIL)and uric acid(UA)in patients with coronary heart disease(CHD).Methods A total of 60 patients with CHD diagnosed in Ningdu County Hospital of Traditional Chinese Medicine from January 2021 to March 2023 were selected as the study subjects and set as CHD group.Another 60 healthy people who underwent physical examination during the same period were selected as healthy group.Serum BIL and UA were detected in both groups.Serum BIL[total bilirubin(TBIL),direct bilirubin(DBIL),indirect bilirubin(IBIL)]and UA test results were compared between CHD group and healthy group.Serum BIL and UA levels in patients with different coronary stenosis grades and different types of CHD were analyzed.Taking the results of coronary angiography as the gold standard,the diagnostic efficacy of serum BIL,UA alone and combined detection on CHD was analyzed.Results The levels of serum TBIL,DBIL and IBIL in CHD group were lower than those in healthy group,and the level of UA was higher than that in healthy group(P<0.05).The levels of BIL,DBIL and IBIL from high to low were gradeⅠ>gradeⅡ>gradeⅢ>gradeⅣ,and the levels of UA from high to low were gradeⅣ>gradeⅢ>gradeⅡ>gradeⅠ(P<0.05).The levels of TBIL,DBIL and IBIL from high to low were stable angina pectoris(SAP)>unstable angina pectoris(UAP)>acute myocardial infarction(AMI),and the levels of UA from high to low were AMI>UAP>SAP(P<0.05).The sensitivity,accuracy and specificity of combined detection of serum BIL and UA in the diagnosis of CHD were higher than those of single detection(P<0.05).Conclusion The detection of serum BIL and UA has a good screening and differential effect on CHD disease,and the combined detection of the two has higher diagnostic efficiency.

关 键 词：冠心病 血清胆红素 尿酸 稳定型心绞痛 不稳定型心绞痛 急性心肌梗死 诊断准确性 

分 类 号：R541.4[医药卫生—心血管疾病] R446.1[医药卫生—内科学]