AHP-CRITIC法结合正交试验法优选如意凝胶贴膏提取工艺  

Optimization of Extraction Process of Ruyi Gel Plaster by AHP-CRITIC Combined with Orthogonal Test

作　　者：刘秋叶 左亚杰[1,2] 何雄 郑沛 文玲 杨俊 王潇[1,2] 文敏 LIU Qiuye;ZUO Yajie;HE Xiong;ZHENG Pei;WEN Ling;YANG Jun;WANG Xiao;WEN Min(The First Affiliated Hospital of Hunan University of Chinese Medicine,Changsha,Hunan,China 410000;Hunan University of Chinese Medicine,Changsha,Hunan,China 410000;Hunan Drug Evaluation and Adverse Reaction Monitoring Center,Changsha,Hunan,China 410000)

机构地区：[1]湖南中医药大学第一附属医院,湖南长沙410000 [2]湖南中医药大学,湖南长沙410000 [3]湖南省药品审评与不良反应监测中心,湖南长沙410000

出　　处：《中国药业》2024年第16期48-51,共4页China Pharmaceuticals

基　　金：国家中医药管理局中药炮制技术传承基地建设项目[国中医药科技中药便函[2022]59号];湖南省自然科学基金[2021JJ80066,2023JJ60112];湖南中医药大学校级科研基金项目[2019XJJJ053]。

摘　　要：目的优选如意凝胶贴膏提取工艺。方法以栀子苷含量、黄芩苷含量和干膏得率为评价指标,采用层次分析(AHP)-CRITIC法确定其权重系数;以加水量、浸泡时间、提取时间为考察因素,采用正交试验法优选如意凝胶贴膏的提取工艺,并验证。结果优选的工艺为第1次加12倍量水,提取2.0 h;第2次加10倍量水,提取1.5 h。按最优工艺进行提取,样品的干膏得率、栀子苷含量、黄芩苷含量分别为24.11%~24.23%、2.20~2.25 mg/g、12.10~12.15 mg/g。结论优选的提取工艺科学、合理,可为如意凝胶贴膏后续的研发提供依据。Objective To optimize the extraction process of Ruyi Gel Plaster.Methods The geniposide content,baicalin content and dry extract yield were taken as the evaluation indicators,the analytic hierarchy process(AHP)-CRITIC method was used to determine their weight coefficients.The orthogonal test was used to optimize the extraction process of Ruyi Gel Plaster with the water addition amount,soaking time and extraction time as the investigation factors.Then the verification test was carried out.Results The optimal process was as follows:adding 12 times the amount of water for the first time,extracting for 2.0 h;adding 10 times the amount of water for the second time,extracting for 1.5 h.Based on the optimal extraction process,the dry extract yield,geniposide content and baicalin content of the samples were in the range of 24.11%-24.23%,2.20-2.25 mg/g and 12.10-12.15 mg/g,respectively.Conclusion The optimal extraction process is scientific and reasonable,which can provide a basis for the follow-up research and development of Ruyi Gel Plaster.

关 键 词：如意凝胶贴膏 提取工艺 层次分析法 客观赋权法 干膏得率 

分 类 号：R94[医药卫生—药剂学]