严重发热伴血小板减少综合征继发肺曲霉感染及吉兰-巴雷综合征个案并文献分析  

Pulmonary Aspergillosis and Guillain-BarréSyndrome Secondary to Severe Fever with Thrombocytopenia Syndrome:A Case Report and Literature Analysis

作　　者：谢晓婷 周冉 XIE Xiaoting;ZHOU Ran(The People's Hospital of Taihe County,Fuyang,Anhui,China 236000;The First Affiliated Hospital of USTC·Anhui Provincial Hospital,Hefei,Anhui,China 230001)

机构地区：[1]安徽省阜阳市太和县人民医院,安徽阜阳236000 [2]中国科学技术大学附属第一医院·安徽省立医院,安徽合肥230001

出　　处：《中国药业》2024年第16期144-148,共5页China Pharmaceuticals

基　　金：安徽省高等学校省级质量工程项目[2021jyxm1798]。

摘　　要：目的提高严重发热伴血小板减少综合征(SFTS)继发肺曲霉感染及吉兰-巴雷综合征(GBS)患者的诊治效果。方法回顾性分析安徽省立医院重症监护室(ICU)收治的1例SFTS继发肺曲霉感染及GBS患者的临床资料,并结合文献对治疗方案进行分析。结果经多学科联合会诊(MDT)团队诊断结合文献分析发现,SFTS继发肺曲霉感染的同时可能会诱发GBS,三病分别以利巴韦林联合血浆置换、艾沙康唑、人免疫球蛋白联合激素冲击治疗处理。治疗后患者病情逐渐改善,转至外院继续康复治疗。结论当SFTS患者出现感觉异常或减退、肢体活动障碍等神经系统异常表现时,需警惕GBS,应及早诊治,以降低患者的死亡率,改善预后。Objective To promote the diagnosis and treatment of pulmonary aspergillosis and Guillain-Barrésyndrome(GBS)secondary to severe fever with thrombocytopenia syndrome(SFTS).Methods The clinical data of a patient with pulmonary aspergillosis and GBS secondary to SFTS admitted to the intensive care unit(ICU)of Anhui Provincial Hospital were retrospectively collected,and the treatment regimen was analyzed based on relevant literature.Results Based on the multi-disciplinary treatment(MDT)and literature analysis,it was found that SFTS might induce GBS when the patient suffered pulmonary aspergillosis secondary to SFTS.SFTS,pulmonary aspergillosis and GBS were treated with ribavirin combined with plasma exchange,isavuconazole,human immunoglobulin combined with hormone pulse therapy respectively.After treatment,the patient′s condition gradually improved,and he was transferred to another hospital for further rehabilitation treatment.Conclusion When the SFTS patients exhibit neurological abnormalities such as sensory abnormalities or decline,limb movement disorders,etc.,GBS needs to be paid attention to and treated early to decrease the patients′mortality and improve the prognosis.

关 键 词：严重发热伴血小板减少综合征 肺曲霉感染 吉兰-巴雷综合征 药学监护 文献分析 

分 类 号：R969.3[医药卫生—药理学]