肝主动靶向载药系统抑制肝癌作用的研究进展  

Research Progress on the Inhibitory Effect of Liver Active-Targeted Drug Delivery System on Liver Cancer

作　　者：凯丽比努尔·奥布力艾散 李倩 尹东锋 Kailibinuer·AOBULIAISAN;LI Qian;YIN Dongfeng(College of Pharmacy,Xinjiang Medical University,Urumqi,Xinjiang,China 830000;General Hospital of Xinjiang Military Command of PLA,Urumqi,Xinjiang,China 830000)

机构地区：[1]新疆医科大学药学院,新疆乌鲁木齐830000 [2]中国人民解放军新疆军区总医院,新疆乌鲁木齐830000

出　　处：《中国药业》2024年第16期149-152,I0001,I0002,共6页China Pharmaceuticals

基　　金：新疆维吾尔自治区自然科学基金重点项目[2022D01D78]。

摘　　要：目的为新型肝主动靶向载药系统的研究和相关制剂的研发提供参考。方法查阅2017年至2023年中国知网、万方、维普、PubMed数据库配体修饰肝主动靶向载药系统相关文献,归纳并总结该系统类型及其用于肝癌治疗的研究现状,包括特异性纳米颗粒的设计、靶向载药系统在体内外的效果和存在的挑战,以及该系统未来的发展方向。结果与结论肝主动靶向载药系统为近年来兴起的新型给药策略,包括肝实质细胞、肝非实质细胞、肝肿瘤细胞3个靶向。肝癌细胞表面的特异性标志物是靶向递送化疗药物的主要目标,纳米颗粒是肝主动靶向载药系统中最常用的药物载体。通过调整纳米颗粒的材料、表面修饰等方法可实现药物向肝癌组织的高效、低毒及特异性递送。因此,尽管肝主动靶向给药系统仍有许多关键技术需要解决,如制备工艺较复杂、载药量小,肝细胞特异性配体发掘和应用不足,大量载体材料尚需完成从试验研究阶段向临床应用的转变,但其在肝癌靶向治疗方面已显示出极大的优越性,其发展趋势和应用前景值得重视。Objective To provide a reference for the research of novel liver active-targeted drug delivery system and related formulations.Methods Based on the literature related to the ligand-modified liver active-targeted drug delivery system in the CNKI,WanFang,VIP and PubMed from 2017 to 2023,the types of the system and its research status in the treatment of liver cancer(including the design of specific nanoparticles,the efficacy of targeted drug delivery system in vitro and in vivo,the existing challenges and the future development direction of this system)were summarized.Results and Conclusion The liver active-targeted drug delivery system is a novel drug delivery strategy emerging in recent years,which targets liver parenchymal cells,liver non-parenchymal cells and liver tumor cells.The specific markers on the surface of liver cancer cells were the main targets for targeted delivery of chemotherapy drugs,and nanoparticles are the most commonly used drug carriers in the liver active-targeted drug delivery system.Efficient,low-toxicity and specific delivery of drugs to liver cancer tissues can be realized by the material adjustment and surface modification of nanoparticles.There are still many key technologies that need to be improved for liver active-targeted drug delivery system,such as complex preparation processes,low drug loading,insufficient exploration and application of liver cell specific ligands,lack of transformation of a large number of carrier materials from experimental research to clinical application.However,the liver active-targeted drug delivery system has shown great superiority in targeted therapy for liver cancer,and its development trend and application prospect are worth paying attention to.

关 键 词：肝癌 靶向载药 主动靶向 受体 配体 

分 类 号：R979.19[医药卫生—药品]