通络开痹片联合高渗葡萄糖关节腔内注射治疗膝骨关节炎的临床疗效  

Clinical effect of Tongluo Kaibi tablet combined with intra-articular injection of hyperosmolar glucose in the treatment of knee osteoarthritis

作　　者：吴建华 杨宝莲 朱小明 孙小波 WU Jianhua;YANG Baolian;ZHU Xiaoming;SUN Xiaobo(Department of Preparation,Ganzhou Hospital of Traditional Chinese Medicine,Ganzhou 341000,Jiangxi,China;Department of Orthopedics,Ganzhou Hospital of Traditional Chinese Medicine,Ganzhou 341000,Jiangxi,China)

机构地区：[1]赣州市中医院制剂室,江西赣州341000 [2]赣州市中医院骨科,江西赣州341000

出　　处：《中国现代医生》2024年第22期84-87,共4页China Modern Doctor

基　　金：江西省卫生健康委科技计划项目(202312106)。

摘　　要：目的探讨通络开痹片联合高渗葡萄糖关节腔内注射治疗膝骨关节炎(knee osteoarthritis,KOA)的疗效。方法选取2023年1月至12月赣州市中医院收治的82例KOA患者,根据随机数字表法将其分为对照组和观察组,每组各41例。对照组患者给予双氯芬酸钠口服+玻璃酸钠关节腔内注射治疗,观察组患者给予通络开痹片口服+高渗葡萄糖关节腔内注射治疗;两组患者均治疗8周。比较两组患者的临床疗效、视觉模拟评分法(visual analogue scale,VAS)评分、Lysholm膝关节评分和炎症因子水平。结果观察组患者的治疗总有效率显著高于对照组(χ^(2)=6.187,P<0.001)。治疗8周后,两组患者的VAS评分、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、白细胞介素-1β(interleukin-1β,IL-1β)、基质金属蛋白酶3(matrix metalloproteinase 3,MMP-3)水平均显著低于本组治疗前,Lysholm膝关节评分均显著高于本组治疗前(P<0.05),且观察组患者的VAS评分、TNF-α、IL-1β、MMP-3水平显著低于对照组,Lysholm膝关节评分显著高于对照组(P<0.05)。结论通络开痹片联合高渗葡萄糖关节腔内注射有助于KOA患者缓解膝关节疼痛、降低炎症因子水平并改善膝关节功能,治疗效果确切。Objective To explore the efficacy of Tongluo Kaibi tablet combined with intra-articular injection of hypertonic glucose in the treatment of knee osteoarthritis(KOA).Methods A total of 82 patients with KOA admitted to Ganzhou Hospital of Traditional Chinese Medicine from January to December 2023 were selected and divided into control group and observation group according to random number table method,with 41 cases in each group.The control group was given diclofenac sodium oral administration+intra-articular injection of sodium hyaluronate,and the observation group was given Tongluo Kaibi tablet oral administration+intra-articular injection of hypertonic glucose.Both groups were treated for 8 weeks.The clinical efficacy,visual analogue scale(VAS)score,Lysholm knee joint score and inflammatory factor levels were compared between two groups.Results The total effective rate of observation group was significantly higher than that of control group(χ^(2)=6.187,P<0.001).After 8 weeks of treatment,VAS score,tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β),matrix metalloproteinase 3(MMP-3)in both groups were significantly lower than before treatment,and Lysholm knee joint scores were significantly higher than before treatment(P<0.05).VAS score,TNF-α,IL-1βand MMP-3 levels in observation group were significantly lower than those in control group,and Lysholm knee joint score was significantly higher than that in control group(P<0.05).Conclusion Tongluo Kaibi tablet combined with intra-articular injection of hypertonic glucose can help KOA patients relieve knee pain,reduce the level of inflammatory factors and improve knee joint function,and the therapeutic effect is accurate.

关 键 词：膝骨关节炎 通络开痹片 关节腔内注射 高渗葡萄糖 炎症因子 

分 类 号：R684.3[医药卫生—骨科学]