重度黄疸换血新生儿闪光视觉诱发电位影响因素分析  

Influencing Factors of Flash-visual Evoked Potentials of Children with Severe Neonatal Hyperbilirubinemia

作　　者：刘俊 王潇潇 徐倩倩 王富明 唐军 Liu Jun;Wang Xiaoxiao;Xu Qianqian(Pediatnic Department,Kaifeng Children’s Hospital,Kaifeng,Henan,475000,China)

机构地区：[1]开封市儿童医院儿科,河南开封475000

出　　处：《黑龙江医学》2024年第15期1805-1807,共3页Heilongjiang Medical Journal

基　　金：开封市科技发展计划项目(2203112)。

摘　　要：目的:回顾性分析重度黄疸换血新生儿闪光视觉诱发电位(F-VEP)影响因素。方法:选取2019年1月—2021年12月开封市儿童医院新生儿科住院的重度高胆红素血症新生儿,找出完成换血退黄治疗且进行F-VEP检查的患儿,记录患儿F-VEP检查结果情况、患儿胎龄、换血时体重、换血时日龄、换血前血清总胆红素(TSB)水平、直接胆红素水平、换血后TSB水平及直接胆红素水平、住院总天数等情况,并根据F-VEP结果分为F-VEP异常组和F-VEP正常组,对两组患儿进行对比。结果:共找到73例重度黄疸换血退黄且进行F-VEP检查的新生儿,其中3例患儿均进行2次换血退黄治疗,故共行76例次换血退黄治疗,73例患儿F-VEP检查中F-VEP异常患儿21例、正常患儿52例。F-VEP异常组的新生儿胎龄、换血时体重均低于F-VEP正常组新生儿,差异有统计学意义(t=-2.317、-2.078,P<0.05)。在F-VEP异常组新生儿换血前TSB水平、换血前直接胆红素(DB)水平、换血后TSB水平、换血时日龄均低于F-VEP正常组新生儿,差异无统计学意义(t=-0.408、-0.816、-0.788、0.121,P>0.05)。F-VEP异常组的新生儿换血后DB水平高于F-VEP正常组新生儿,差异无统计学意义(t=-0.121,P>0.05)。F-VEP异常组的新生儿住院天数少于F-VEP正常组,差异无统计学意义(t=-0.079,P>0.05)。结论:部分重度黄疸换血退黄新生儿存在F-VEP异常,胎龄偏小、换血时体重偏低患儿更易出现F-VEP异常。因此,对小胎龄、体重偏低重症黄疸新生儿需加强F-VEP监测以提高F-VEP异常检出率并进行及时干预。Objective:To retrospectively analyze the influencing factors of flash visual evoked potential(F-VEP)of children with severe neonatal hyperbi lirubinemia.Methods:Searching neonates with severe hyperbilirubinemia who were hospitalized in NICU of the hospital from January 2019 to December 2021 to find out the children who had completed simultaneous peripheral arteriovenous exchange transfusion treatment and underwent F-VEP examination.The data were recorded,such as the results of F-VEP,gestational age,weight and age at blood exchange,serum total bilirubin level and direct bilirubin level before blood exchange,serum total bilirubin level and direct bilirubin level after blood exchange and total days of hospital stay,etc.According to the results of F-VEP,all the neonates were divided into two groups:abnormal F-VEP group and normal F-VEP group,and the data were compared.Results:A total of 73 neonates with severe jaundice were found who underwent F-VEP examination after simultaneous peripheral arteriovenous exchange transfusion treatment,of which 3 neonates were treated with 2 times of exchange transfusion treatment.As a result,there were a total of 76 times of exchange transfusion and 73 times of F-VEP.21 of the 73 times were abnormal F-VEP and 52 times were normal F-VEP.Gestational age and body weight in the abnormal F-VEP group were lower than those in the normal F-VEP group,and the differences between the two groups were statistically significant(t=-2.317,-2.078;P<0.05).Serum total bilirubin(TSB)level before blood exchange,direct bilirubin(DB)level before blood exchange,serum total bilirubin level after blood exchange,age when blood exchange in abnormal F-VEP group were lower than those in the normal F-VEP group respectively.However,there was no statistical significance between the two groups(t=-0.408,-0.816,-0.788,0.121;P>0.05).The level of direct bilirubin(DB)after blood exchange in the group with abnormal F-VEP was higher than that in the group with normal F-VEP,with no significant difference between the two grou

关 键 词：新生儿重度黄疸 换血 闪光视觉诱发电位 胎龄 

分 类 号：R272.1[医药卫生—中医儿科学]