血清PCT、CRP、IL-6及25-羟维生素D3检测在婴幼儿肺炎诊断中应用探析  

Application of Serum PCT,CRP,IL-6,and 25-hydroxyvitamin D3 Detection in the Diagnosis of Infant Pneumonia

作　　者：张彬 Zhang Bin(Laboratory Department,Zhengzhou Maternal and Child Health Hospital,Zhengzhou,Henan,450000,China)

机构地区：[1]郑州市妇幼保健院检验科,河南郑州450000

出　　处：《黑龙江医学》2024年第16期1964-1966,共3页Heilongjiang Medical Journal

摘　　要：目的:探讨血清降钙素原(PCT)、C反应蛋白(CRP)、白介素-6(IL-6)及25-羟维生素D3[25-(OH)D3]检测在婴幼儿肺炎诊断中的临床价值。方法:选取2021年1月—2022年12月郑州市妇幼保健院收治的58例肺炎患儿作为观察组,另选同期健康婴幼儿58例作为对照组。均采血开展PCT、CRP、IL-6、25-(OH)D3检测,比较两组婴幼儿PCT、CRP、IL-6及25-(OH)D3水平差异;并依据患儿肺炎严重程度分为轻症、重症,比较两组婴幼儿PCT、CRP、IL-6及25-(OH)D3水平差异;绘制工作特征ROC,分析PCT、CRP、IL-6、25-(OH)D3及联合检测诊断婴幼儿肺炎的临床价值。结果:观察组患儿PCT、CRP、IL-6水平高于对照组,25-(OH)D3水平低于对照组,差异有统计学意义(t=35.297、60.378、45.650、38.521,P<0.05);58例肺炎患儿,其中轻症39例,重症19例;重症患儿PCT、CRP、IL-6高于轻症患儿,25-(OH)D3水平低于轻症患儿,差异有统计学意义(t=20.701、20.804、15.107、16.427,P<0.05);绘制ROC显示,PCT、CRP、IL-6、25-(OH)D3及联合检测诊断婴幼儿肺炎的曲线下面积为0.837、0.825、0.780、0.846、0.951,联合检测价值最高。结论:血清PCT、CRP、IL-6及25-(OH)D3在婴幼儿肺炎诊断中具有一定价值,联合检测可进一步提高诊断效能,减少漏诊、误诊风险,可评估病情严重程度,有助于指导临床治疗方案制定。Objective:To explore the clinical value of serum procalcitonin(PCT),C-reactive protein(CRP),interleukin-6(IL-6),and 25-hydroxyvitamin D3[25-(OH)D3]detection in the diagnosis of infant pneumonia.Methods:58 children with pneumonia admitted to the hospital from 2021 to December 2022 were selected as the observation group,and another 58 healthy infants and young children in the same period were selected as the control group.Blood samples were collected for PCT,CRP,IL-6,and 25-(OH)D3 testing,and the differences in PCT,CRP,IL-6 and 25-(OH)D3 levels between the two groups were compared.According to the severity of the pneumonia in the children,they were divided into mild and severe cases,and the differences in PCT,CRP,IL-6,and 25-(OH)D3 levels between the two groups were compared.ROC were drawn to analyze the clinical value of PCT,CRP,IL-6 and 25-(OH)D3,and combined detection in the diagnosis of infant pneumonia.Results:The levels of PCT,CRP and IL-6 in the observation group were higher than those in the control group,while the level of 25-(OH)D3 was lower than those in the control group,with statistically significant differences(t=35.297,60.378,45.650,38.521;P<0.05).Among 58 children with pneumonia,there were 39 mild cases and 19 severe cases.The levels of PCT,CRP and IL-6 in critically ill patients were higher than those in mild patients,while the levels of 25-(OH)D3 were lower than those in mild patients,with statistically significant differences(t=20.701,20.804,15.107,16.427;P<0.05).According to ROC,the area under the curve for PCT,CRP,IL-6,25-(OH)D3,and combined detection in the diagnosis of infant pneumonia was 0.837,0.825,0.780,0.846 and 0.951,with the highest value of combined detection.Conclusion:Serum PCT,CRP,IL-6,and 25-(OH)D3 have certain value in the diagnosis of infant pneumonia.Combined detection can further improve diagnostic efficiency,reduce the risk of missed diagnosis and misdiagnosis,and evaluate the severity of the condition,which helps guide the development of clinical treatment plans.

关 键 词：婴幼儿肺炎 降钙素原 C反应蛋白 白介素-6 25-羟维生素D3 诊断价值 

分 类 号：R375.2[医药卫生—病原生物学]