喘息婴幼儿血清YKL-40、IL-8水平与潮气肺功能的相关性研究  

Correlation between serum YKL-40,IL-8 levels and tital breathing pulmonary function in infants and toddlers with wheezing

作　　者：王淑玉[1] 郑一博[1] 杨蕾 李矢云 马晓琳 刘凡 张伟 WANG Shu-yu;ZHENG Yi-bo;YANG Lei;LI Shi-yun;MA Xiao-lin;LIU Fan;ZHANG Wei(Department of Pediatrics,Bethune International Peace Hospital,Shijiazhuang 050082,Hebei,CHINA)

机构地区：[1]白求恩国际和平医院儿科,河北石家庄050082

出　　处：《海南医学》2024年第16期2353-2356,共4页Hainan Medical Journal

基　　金：河北省卫生健康委员会重点科技研究计划课题(编号:20211386)。

摘　　要：目的探讨血清几丁质酶3样蛋白1(YKL-40)、白细胞介素-8(IL-8)水平在不同严重程度喘息婴幼儿中的变化及其与潮气肺功能的相关性。方法选择2021年6月至2023年5月白求恩国际和平医院儿科收治的喘息急性发作婴幼儿70例,根据症状的严重程度分为轻症组44例和重症组26例,选择同期来我院体检的健康婴幼儿22例作为对照组。采用酶联免疫吸附测定(ELISA)法检测各组婴幼儿的血清YKL-40、IL-8水平,并测查潮气呼吸肺功能,采用Pearson相关分析法分析YKL-40与IL-8与潮气肺功能参数的相关性。结果重症组患儿的血清YKL-40和IL-8水平分别为(56.81±13.48)ng/mL、(192.89±51.11)pg/mL,明显高于轻症组的(43.48±14.61)ng/mL、(148.84±54.13)pg/mL和对照组的(29.06±10.24)ng/mL、(94.45±23.94)pg/mL,而轻症组患儿的血清YKL-40、IL-8水平又明显高于对照组,差异均有统计学意义(P<0.05);重症组、轻症组和对照组婴幼儿的潮气量(VT/kg)、吸气时间(TI)和呼气时间(TE)比较差异均无统计学意义(P>0.05);重症组患儿的吸气时间与呼气时间比(TI/TE)、达峰容积比(VPEF/VE)和达峰时间比(TPTEF/TE)分别为0.60±0.11、(21.53±5.44)%、(18.17±4.85)%,明显低于轻症组的0.68±0.12、(25.92±6.48)%、(23.51±8.63)%和对照组的0.72±0.18、(35.62±6.24)%、(34.26±7.16)%,轻症组患儿TI/TE、VPEF/VE、TPTEF/TE明显低于对照组,差异均有统计学意义(P<0.05)。Pearson相关分析结果显示,血清YKL-40与IL-8呈正相关(r=0.926,P<0.05),与VPEF/VE及TPTEF/TE呈负相关(r=-0.725、-0.827,P<0.05),YKL-40与VT/kg、TI、TE及TI/TE无明显相关性(r=-0.294、-0.469、0.247、-0.387,P>0.05)。结论YKL-40和IL-8可能参与了婴幼儿喘息的急性气道炎症过程,且与喘息严重程度及肺小气道功能相关。Objective To investigate the changes of serum YKL-40,IL-8 in infants and toddlers with different severity of wheezing and their correlation with tital breathing pulmonary function.Methods Seventy infants and toddlers with acute attack of wheezing admitted to Bethune International Peace Hospital from June 2021 to May 2023 were selected in the study.According to the condition,they were divided into mild wheezing group(44 cases)and severe wheezing group(26 cases).Another 22 healthy infants and toddlers undergoing physical examination during the same period were selected as controls(control group).Serum YKL-40,IL-8 levels were detected by enzyme-linked immunosorbent assay(ELISA),tital breathing pulmonary function were tested during the same period,and Pearson correlation analysis were used to analyze the relationship between serum YKL-40,IL-8 and tital breathing pulmonary function.Results The level of serum YKL-40 and IL-8 in severe wheezing group were(56.81±13.48)ng/mL and(192.89±51.11)pg/mL,respectively,which were significantly higher than(43.48±14.61)ng/mL and(148.84±54.13)pg/mL in mild wheezing group and(29.06±10.24)ng/mL and(94.45±23.94)pg/mL in control group;the levels in mild wheezing group were significantly higher than those in the control group;the differences were statistically significant(P<0.05).The tidal volume(VT/kg),inspiration time(TI),and expiratory time(TE)were not statistically different among the three groups(P>0.05).The values of TI/TE,volume to peak tidal expiratory flow as a proportion of exhaled volume(VPEF/VE),time to peak tidal expiratory flow as a proportion of expiratory time(TPTEF/TE)in severe wheezing group were 0.60±0.11,(21.53±5.44)%,(18.17±4.85)%,which were significantly lower than 0.68±0.12,(25.92±6.48)%,(23.51±8.63)%in mild wheezing group and 0.72±0.18,(35.62±6.24)%,(34.26±7.16)%in the control group(P<0.05);the values in mild wheezing group were significantly lower than those in the control group;the differences were statistically significant(P<0.05).Pearson correlat

关 键 词：喘息 几丁质酶3样蛋白1 白细胞介素-8 潮气肺功能 婴幼儿 

分 类 号：R725.6[医药卫生—儿科]